Atypical Brain Asymmetry in Human Situs Inversus: Gut Feeling or Real Evidence?

The alignment of visceral and brain asymmetry observed in some vertebrate species raises the question of whether this association also exists in humans. While the visceral and brain systems may have developed asymmetry for different reasons, basic visceral left–right differentiation mechanisms could have been duplicated to establish brain asymmetry. We describe the main phenotypical anomalies and the general mechanism of left–right differentiation of vertebrate visceral and brain laterality. Next, we systematically review the available human studies that explored the prevalence of atypical behavioral and brain asymmetry in visceral situs anomalies, which almost exclusively involved participants with the mirrored visceral organization (situs inversus). The data show no direct link between human visceral and brain functional laterality as most participants with situs inversus show the typical population bias for handedness and brain functional asymmetry, although an increased prevalence of functional crowding may be present. At the same time, several independent studies present evidence for a possible relation between situs inversus and the gross morphological asymmetry of the brain torque with potential differences between subtypes of situs inversus with ciliary and non-ciliary etiologies.

Asymmetric Behavior in Ptyodactylus guttatus: Can a Digit Ratio Reflect Brain Laterality?

The digit ratio, an indicator of brain laterality, is the ratio of the second and fourth digits on the left (L24) or right foot (R24). Much of the research on the digit ratio and brain laterality focuses on primates, rather than other species such as reptiles. We tested whether the digit ratio in the gecko Ptyodactylus guttatus was associated with behaviors attributed to brain laterality. We examined risk-taking behavior (time spent under cover), foot preference (which foot was the first to start moving) and the side from which geckos bypassed an obstacle, in relation to the digit ratio. Geckos with longer fourth digits on their left hind foot (higher digit ratio) spent more time under cover. Geckos starting to move with their left leg were much more likely to bypass obstacles from the right side, and vice versa. This is the first evidence of laterality being associated with the digit ratio in reptiles. Comparisons among vertebrates are needed in order to decipher the evolutionary origin of the commonalities and peculiarities of brain asymmetry and disentangle the patterns and drivers of our evolutionary tree.

Atypical brain asymmetry in autism – a candidate for clinically meaningful stratification

BackgroundAutism Spectrum Disorder (henceforth ‘autism’) is a highly heterogeneous neurodevelopmental condition with few effective treatments for core and associated features. To make progress we need to both identify and validate neural markers that help to parse heterogeneity to tailor therapies to specific neurobiological profiles. Atypical hemispheric lateralization is a stable feature across studies in autism, however its potential of lateralization as a neural stratification marker has not been widely examined.MethodsIn order to dissect heterogeneity in lateralization in autism, we used the large EU-AIMS Longitudinal European Autism Project dataset comprising 352 individuals with autism and 233 neurotypical (NT) controls as well as a replication dataset from ABIDE (513 autism, 691 NT) using a promising approach that moves beyond mean-group comparisons. We derived grey matter voxelwise laterality values for each subject and modelled individual deviations from the normative pattern of brain laterality across age using normative modeling.ResultsResults showed that individuals with autism had highly individualized patterns of both extreme right- and leftward deviations, particularly in language-, motor- and visuospatial regions, associated with symptom severity. Language delay (LD) explained most variance in extreme rightward patterns, whereas core autism symptom severity explained most variance in extreme leftward patterns. Follow-up analyses showed that a stepwise pattern emerged with individuals with autism with LD showing more pronounced rightward deviations than autism individuals without LD.ConclusionOur analyses corroborate the need for novel (dimensional) approaches to delineate the heterogeneous neuroanatomy in autism, and indicate atypical lateralization may constitute a neurophenotype for clinically meaningful stratification in autism.

The Kayahara Silhouette Illusion

Since it was first published online by Japanese artist Nobuyuki Kayahara, the spinning silhouette of a young girl (the spinning dancer illusion) has been reposted on countless websites where it serves as an eye-catcher that lures users into clicking their way toward different forms of commercial advertisements. Spinning about a vertical axis, the perception of the figure is bistable: it can be seen as either spinning clockwise or counterclockwise, with the former interpretation apparently dominating the latter. This asymmetry generated a number of weird theories about brain laterality that further contributed to the popularity of the Kayahara silhouette on the Internet. These theories are obviously not backed by any serious research, but the animation is in fact a puzzling visual illusion. Primarily based on depth ambiguity, it employs the viewing-from-above bias and offers a number of sophisticated perceptual conflicts.