BRAIN DEATH DIAGNOSIS IN SEVERE TRAUMATIC BRAIN INJURY (TBI)

Проведено клинико-неврологическое и инструментальное исследование смерти мозга у 23 пациентов с тяжелой черепно-мозговой травмой за 2020 год. Результаты исследования показали, что летальность в первые 72 часа была в 14 случаях - 60,9%. Досуточная летальность составила 9 случаев - 39,1 %. Пациенты трудоспособного возраста составили 83%. В большинстве случаев клиническая картина смерти мозга осложнялась наличием травм лица, спонтанными или индуцированными автоматизмами, ушибом легких при сочетанной травме. В данной статье описаны виды клинических исследований, используемых в диагностике смерти мозга, в сложных случаях дополнительных подтверждающих тестов. Research has been done of 23 patients with а severe traumatic brain injury (TBI) in 2020. Outcomes of our research have indicated mortality in the first 72 hours was in 14 cases - 60,9%.And the first day lethality was 9 cases - 39,1%. The significant quantity of working age patients amounts to 83%. Generally, brain death in any patient with catastrophic brain injury and a bedside exam consistent with brain death complicated by facial injuries, spontaneous or induced automatism, lungs contusion with concomitant injury. The article describes types of clinical examination, used in the definition of brain death. In complicated cases, supplementary confirm tests.

Cultural sensitivity in brain death determination: a necessity in end-of-life decisions in Japan

Background In an increasingly globalized world, legal protocols related to health care that are both effective and culturally sensitive are paramount in providing excellent quality of care as well as protection for physicians tasked with decision making. Here, we analyze the current medicolegal status of brain death diagnosis with regard to end-of-life care in Japan, China, and South Korea from the perspectives of front-line health care workers. Main body Japan has legally wrestled with the concept of brain death for decades. An inability to declare brain death without consent from family coupled with cultural expectations of family involvement in medical care is mirrored in other Confucian-based cultures (China and South Korea) and may complicate care for patients from these countries when traveling or working overseas. Within Japan, China, and South Korea, medicolegal shortcomings in the diagnosis of brain death (and organ donation) act as a great source of stress for physicians and expose them to potential public and legal scorn. Here, we detail the medicolegal status of brain death diagnosis within Japan and compare it to China and South Korea to find common ground and elucidate the impact of legal ambiguity on health care workers. Conclusion The Confucian cultural foundation of multiple Asian countries raises common issues of family involvement with diagnosis and cultural considerations that must be met. Leveraging public education systems may increase awareness of brain death issues and lead to evolving laws that clarify such end-of-life issues while protecting physicians from sociocultural backlash.

Brain-Dead and Coma Patients Exhibit Different Serum Metabolic Profiles: A Novel Diagnostic Approach in Neurocritical Care

There is a clear difference between severe brain damage and brain death. However, in clinical practice, the differentiation of these states can be challenging. Currently, there are no laboratory tools that facilitate brain death diagnosis. The aim of our study was to evaluate the utility of serum metabolomic analysis in differentiating coma patients (CP) from individuals with brain death (BD). Serum samples were collected from 23 adult individuals with established diagnosis of brain death and 24 patients in coma with Glasgow Coma Scale 3 or 4, with no other clinical symptoms of brain death for at least 7 days after sample collection. Serum metabolomic profiles were investigated using proton nuclear magnetic resonance (NMR) spectroscopy. The results obtained were examined by univariate and multivariate data analysis (PCA, PLS-DA, and OPLS-DA). Metabolic profiling allowed us to quantify 43 resonance signals, of which 34 were identified. Multivariate statistical modeling revealed a highly significant separation between coma patients and brain-dead individuals, as well as strong predictive potential. The findings not only highlight the potential of the metabolomic approach for distinguishing patients in coma from those in the state of brain death but also may provide an understanding of the pathogenic mechanisms underlying these conditions.