allograft kidney
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2022 ◽  
Vol 24 (1) ◽  
Author(s):  
David R. Spiegel ◽  
Ayan Ali ◽  
Cassandra Dao ◽  
Bryce Aidukaitis ◽  
Neha Agrawal ◽  
...  

2022 ◽  
pp. 100411
Author(s):  
Jonathan E. Zuckerman ◽  
John Brealey ◽  
Julie M. Yabu ◽  
Anthony Chang

2021 ◽  
Vol 35 (1) ◽  
pp. S100-S100
Author(s):  
Hardi Yanis ◽  
Marna Ismi ◽  
Desi Salwani ◽  
Abdullah Abdullah ◽  
Maimun Syukri

Author(s):  
Ertugrul Erken ◽  
Mahmut Egemen Senel ◽  
Suzan Dinkci ◽  
Ozlem Goruroglu Ozturk ◽  
Orcun Altunoren ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xiaohu Li ◽  
Wenlong Yue ◽  
Guiwen Feng ◽  
Jinfeng Li

Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the progression of acute and chronic kidney damage and the recovery of allograft kidney function by regulating the BMP and Wnt signaling pathways. Moreover, USAG-1 has been found to be involved in the process of T cell immune response, and its ability to inhibit germinal center activity and reduce humoral immunity is of great significance for the treatment of autoimmune nephropathy and antibody-mediated rejection (AMR) after renal transplantation. This article summarizes the many advances made regarding the roles of USAG-1 in the progression of kidney disease and outlines potential treatments.


Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1054
Author(s):  
Torsten R. Goesch ◽  
Nancy A. Wilson ◽  
Weifeng Zeng ◽  
Bret M. Verhoven ◽  
Weixiong Zhong ◽  
...  

Allograft kidney transplantation, which triggers host cellular- and antibody-mediated rejection of the kidney, is a major contributor to kidney damage during transplant. Here, we asked whether PrC-210 would suppress damage seen in allograft kidney transplant. Brown Norway (BN) rat kidneys were perfused in situ (UW Solution) with or without added 30 mM PrC-210, and then immediately transplanted into Lewis (LEW) rats. 20 h later, the transplanted BN kidneys and LEW rat plasma were analyzed. Kidney histology, and kidney/serum levels of several inflammation-associated cytokines, were measured to assess mismatch-related kidney pathology, and PrC-210 protective efficacy. Twenty hours after the allograft transplants: (i) significant histologic kidney tubule damage and mononuclear inflammatory cell infiltration were seen in allograft kidneys; (ii) kidney function metrics (creatinine and BUN) were significantly elevated; (iii) significant changes in key cytokines, i.e., TIMP-1, TNF-alpha and MIP-3A/CCL20, and kidney activated caspase levels were seen. In PrC-210-treated kidneys and recipient rats, (i) kidney histologic damage (Banff Scores) and mononuclear infiltration were reduced to untreated background levels; (ii) creatinine and BUN were significantly reduced; and (iii) activated caspase and cytokine changes were significantly reduced, some to background. In conclusion, the results suggest that PrC-210 could provide broadly applicable organ protection for many allograft transplantation conditions; it could protect transplanted kidneys during and after all stages of the transplantation process—from organ donation, through transportation, re-implantation and the post-operative inflammation—to minimize acute and chronic rejection.


2021 ◽  
Vol 12 ◽  
Author(s):  
Jose Luis Santiago ◽  
Luis Sánchez-Pérez ◽  
Isabel Pérez-Flores ◽  
Maria Angeles Moreno de la Higuera ◽  
Natividad Calvo Romero ◽  
...  

The genes CD28, CD86 and CTLA-4 conform the costimulatory (CD28-CD86) or inhibitory (CTLA-4-CD86) signal in T-cell activation. T-cell immune response has a critical role in allograft rejection, and single nucleotide polymorphisms (SNPs) located in these genes have been widely analyzed with controversial results. We analyzed a group of SNPs located in the three genes: CD28: rs3116496; CD86: rs1129055; and CTLA-4: rs231775 and rs3087243 in a cohort of 632 consecutively recruited kidney transplanted subjects. All polymorphisms were genotyped by TaqMan chemistry and the diagnosis of rejection was confirmed by biopsy and categorized according to the Banff classification. The analyses showed a statistically significant protective effect to T cell-mediated rejection (TCMR) in carriers of the CTLA-4 rs3087243*G allele, especially in patients with TCMR Banff ≥2 in the overall cohort and in patients without thymoglobulin induction therapy. Both associations were corroborated as independent factors in the multivariate analysis. Interestingly, associations with rejection were not found for any SNP in patients with thymoglobulin induction therapy. As expected, considering the major role of these genes in T-cell activation, no effect was observed for antibody-mediated rejection (ABMR). In conclusion, the SNP rs3087243 located in the CTLA-4 gene may be considered a useful independent biomarker for TCMR risk especially for severe TCMR in patients who did no received thymoglobulin induction therapy.


Heliyon ◽  
2021 ◽  
pp. e07189
Author(s):  
Wichien Sirithanaphol ◽  
Natthida Incharoen ◽  
Ukrit Rompsaithong ◽  
Pakorn Kiatsopit ◽  
Supanut Lumbiganon ◽  
...  

2021 ◽  
Author(s):  
Cornelia Thoeni ◽  
Michael Ordon ◽  
Adriana Krizova ◽  
Kiran Jakate ◽  
Rola Saleeb
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