Self-Voluntary Polymerization with Formation of Quaternary Ammonium Groups

The reaction of spontaneous polymerization in the N, N-dialkylaminoethyl methacrylate - alkyl halide system in organic solvent solutions is considered. It is shown that polymerization in the system under study begins only after the formation of quaternary ammonium salt in the reaction medium (at a concentration of about 0.2 mol/L) by the Menshutkin reaction, as a result of quaternization of the unsaturated amine with an alkyl halide. For the explanation of the aggregate of the obtained experimental data, fundamental considerations were formulated, kinetic schemes were developed, and the corresponding mechanism of polymerization processes was proposed.

Peculiar Properties of Spontaneous Methacrylate Derivatives Polymerization with Haloidallyl Compounds

The reaction of spontaneous polymerization in the system of N, N-diethylaminoethyl methacrylate with allyl chloride and bromide, orthophosphoric acid in ethanol and dimethyl sulfoxide solutions is considered. Spontaneous polymerization proceeds, consisting of two stages: the quaternization reaction and the polymerization reaction. It was shown that the accompanying reaction of quaternization, spontaneous polymerization, takes place both in a mixture of reagents and in the presence of a solvent, in other words, and by mixing an unsaturated amine and an alkyl halide.

Reactivity of heterodiene metal carbonyl complexes

Addition of hard nucleophiles to iron tricarbonyl complexes of α,β-unsaturated ketones and iron tetracarbonyl complexes of α,β-unsaturated esters produces γ-ketocarbonyl compounds. Nucleophilic addition to iron tricarbonyl complexes of α,β-unsaturated imines leads either to pyrrole or α,β-unsaturated amine formation

11-(4-Piperidylidene)-6,11-dihydrodibenzo[b,e]thiepins as potential antipsychotic agents; Synthesis and pharmacology

The secondary amine VIIIb, prepared by demethylation of 2-chloro-11-(1-methyl-4-piperidylidene)-6,11-dihydrodibenzo[b,e]thiepin (IVb), afforded by alkylation with 2-bromoethanol the amino alcohol Vb which was esterified to the decanoate VIb. A reaction of 5-fluorophthalide with the sodium salt of 4-chlorothiophenol in boiling 1-butanol gave the acid X which afforded by cyclization 2-chloro-8-fluorodibenzo[b,e]thiepin-11(6H)-one (XII). Treatment with 1-methyl-4-piperidylmagnesium chloride resulted in the tertiary alcohol IXc which was transformed by an acid catalyzed dehydration to the desired unsaturated amine IVc. While compounds Vb and IVc showed properties of mild tranquillizers, the ester VIb, surprisingly, brought about a mild dopaminomimetic activity (it potentiates the action of apomorphine, has anticataleptic activity and lowers the homovanillic acid level in the striatum of rat brain.