A Single Center Study on the Risks of Peri-Intervention Stroke in Thoracic Endovascular Aortic Repair (TEVAR) and Endovascular Abdominal Aortic Repair (EVAR)

(1) Background: The risk factors of peri-intervention stroke (PIS) in thoracic endovascular aortic repair (TEVAR) and endovascular abdominal aortic repair (EVAR) are different. This study aimed to compare the risks of PIS in both interventions. (2) Methods: Patients who had suffered a PIS related to TEVAR or EVAR from January 2008 to June 2015 in Songklanagarind Hospital were selected as the cases, while patients who had not suffered PIS were randomly selected to create a 1:4 case: control ratio for analysis. The associations between the factors from pre- to post-intervention and PISs in TEVAR or EVAR cases were analyzed by univariable analysis (p < 0.1). The independent risks of PIS were identified by multivariable analysis and presented in odds ratios (p < 0.05). (3) Results: A total of 17 (2.2%) out of 777 patients who had undergone TEVAR or EVAR experienced PIS, of which 9/518 (1.7%) and 8/259 (3.1%) cases were in TEVAR and EVAR groups, respectively. PIS developed within the first 24 h in nine (52.9%) cases. Large vessel ischemic stroke or watershed infarctions were the most common etiologies of PIS. The independent risks of PIS were the volume of intra-intervention blood loss (1.99 (1.88–21.12), p < 0.001) in the TEVAR-related PIS, and intervention time (2.16 (1.95–2.37), p = 0.010) and post-intervention hyperglycemia (18.60 (1.60–216.06), p = 0.001) in the EVAR-related PIS. There were no differences in the rate of PIS among the operators, intervention techniques, and status of the interventions performed. (4) Conclusion: The risks of PIS in TEVAR or EVAR in our center were different and possibly independent of the operator expertise and intervention techniques.

Computed Tomography Imaging Agent Based on Gold Nanoparticles for Internal Iliac Artery Embolization after Endovascular Abdominal Aortic Repair and CCN3 Protection Mechanism

Abdominal aortic aneurysm is more stressful and has more complications in many diseases. During treatment and repair, arteriosclerosis, abdominal congestion deposition, and abdominal swelling cannot be eliminated. In this paper, we used the seed growth method to obtain gold nanoparticles (AuNPs) with good morphology and dispersion. The AuNPs of larger aspect ratio synthesized in this experiment moved their longitudinal plasmon resonance absorption peak to the near-infrared region, which provided suitable materials for subsequent experiments and laid the foundation for the photothermal therapy of tumors. Experiments show that near-infrared rays can penetrate into deep tissues to overcome the shortcomings that visible light cannot penetrate abdominal aorta well. AuNPs absorb near-infrared rays, thereby generating heat energy to achieve the purpose of treating tumors. In addition, AuNPs also have fluorescent properties, combined with other forms of imaging methods, to achieve the purpose of multimodal imaging, and improve the diagnostic accuracy of studying the protection mechanism of the nephroblastoma overexpressed (NOV or CCN3) gene.