A Rare Case of Pulmonary Carcinosarcoma with Unusual Presentation: A Diagnostic Dilemma

Pulmonary carcinosarcoma is a rare malignancy of the lung and has poor prognosis than non-small cell lung cancer. Effective treatment has not been developed for non-resect able advanced stage. We report a case in a 51-year-old female who presented with a right sided massive pleural effusion. Pleural biopsy tissue histology and immunohistochemistry revealed carcinosarcoma.

Lung Carcinosarcoma Report of One Case Treated With Immunotherapy with Review

Pulmonary Carcinosarcoma is an uncommon malignant biphasic tumor that accounts for less than 1% of all lung cancers. It is defined by coexisting histologic elements of carcinomatous and sarcomatous components. We report a case of advanced stage pulmonary carcinosarcoma in a 83-year-old patient, treated with immunotherapy with good response lasted for more than one year.

The characteristic of tumor immune microenvironment in pulmonary carcinosarcoma

Pulmonary carcinosarcoma (PCS) is a rare but aggressive neoplasm, due to late diagnosis and early metastasis. Surgery combined with radiotherapy is a standard treatment. However, PCS features an easy relapse after surgery resection and resistance to chemotherapy and radiotherapy. Tumor immune microenvironment reflects tumor immunophenotyping and affects immunotherapy efficiency. This review summarized current studies on the characteristic of tumor immune microenvironment in PCS and discussed the potential of immunotherapy combined with other regimes strategy as a candidate for treatments in PCS.