Altered Sensitivity to Motion of Area MT Neurons Following Long-Term V1 Lesions

Primates with primary visual cortex (V1) damage often retain residual motion sensitivity, which is hypothesized to be mediated by middle temporal area (MT). MT neurons continue to respond to stimuli shortly after V1 lesions; however, experimental and clinical studies of lesion-induced plasticity have shown that lesion effects can take several months to stabilize. It is unknown what physiological changes occur in MT and whether neural responses persist long after V1 damage. We recorded neuronal responses in MT to moving dot patterns in adult marmoset monkeys 6–12 months after unilateral V1 lesions. In contrast to results obtained shortly after V1 lesions, we found that fewer MT neurons were direction selective, including neurons expected to still receive projections from remaining parts of V1. The firing rates of most cells increased with increases in motion strength, regardless of stimulus direction. Furthermore, firing rates were higher and more variable than in control MT cells. To test whether these observations could be mechanistically explained by underlying changes in neural circuitry, we created a network model of MT. We found that a local imbalance of inhibition and excitation explained the observed firing rate changes. These results provide the first insights into functional implications of long-term plasticity in MT following V1 lesions.

Residual Motion Error Correction with Backprojection Multisquint Algorithm for Airborne Synthetic Aperture Radar Interferometry

For airborne interferometric synthetic aperture radar (InSAR) data processing, it is essential to achieve precise motion compensation to obtain high-quality digital elevation models (DEMs). In this paper, a novel InSAR motion compensation method is developed, which combines the backprojection (BP) focusing and the multisquint (MSQ) technique. The algorithm is two-fold. For SAR image focusing, BP algorithm is applied to fully use the navigation information. Additionally, an explicit mathematical expression of residual motion error (RME) in the BP image is derived, which paves a way to integrating the MSQ algorithm in the azimuth spatial wavenumber domain for a refined RME correction. It is revealed that the proposed backprojection multisquint (BP-MSQ) algorithm exploits the motion error correction advantages of BP and MSQ simultaneously, which leads to significant improvements of InSAR image quality. Simulation and real data experiments are employed to illustrate the effectiveness of the proposed algorithm.