Chemoprevention in Breast Cancer

Chemoprevention in breast cancer represents one of the most important therapeutic regimens in an effort to optimize survival and prevent breast cancer recurrence. The chapter aims to analyze below all potential medical regimens used in breast cancer chemoprevention, along with explaining the reasons why those are the ones selected: their characteristics, their mechanism of action, and their side effects. Among these, we may report tamoxifen, raloxifen, aromatase inhibitors, and new therapeutic regimens such as polyphenoles.

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This review summarizes the current findings concerning the molecular mechanisms of bioactive compounds from grapes and red wine and their metabolites on breast cancer—the most commonly occurring cancer in women—chemoprevention and treatment. Flavonoid compounds like flavonols, monomeric catechins, proanthocyanidins, anthocyanins, anthocyanidins and non-flavonoid phenolic compounds, such as resveratrol, as well as their metabolites, are discussed with respect to structure and metabolism/bioavailability. In addition, a broad discussion regarding in vitro, in vivo and clinical trials about the chemoprevention and therapy using these molecules is presented.