The rise of regulation is perhaps one of the most critical transformations of the capitalist system. Not surprisingly, this development has triggered a surge in the interest in regulation in social and political sciences since the 1990s. A contested notion, regulation can denote different meanings and can be understood in different ways. Given this multiplicity of meanings, studying regulatory cooperation requires exploring some fundamental elements to understand the main concepts and approaches used, and to capture its multiple levels and dimensions. The adopted denominations and utilized concepts are many—“regional regulatory cooperation,” “regional regulatory regime,” “regional regulatory integration,” “regulatory regionalism,” and “regional regulatory governance,” among others—and each captures, in its own way, particular dimensions or aspects of the field. In terms of levels, whereas a rich and dense literature has attested to the fact that global governance increasingly proceeds through transnational regulations, studies with a focus on the regional level are scant, especially when compared to the former, and remain scattered under various labels and denominations. However, regulatory cooperation leads to the creation of regulatory spaces that blur the distinction not only between the national and global arenas, but also between the national and the regional. Studies have thus translated these theoretical claims into empirical research showing that there is a growing regulatory cooperation space at the regional level, where various constellations of actors and networks that bridge the state and nonstate, and public and private, distinctions operate across levels and policy sectors. Analyses and scholarship on regulation and regulatory cooperation have made relevant progress, and in so doing, they have opened new avenues for research to explore and understand the place and role of regulatory cooperation and regions in a complex regulatory world.