AbstractLet {\mathbb{H}} be a separable Hilbert space. In this paper, we establish a generalization of Walnut’s representation and Janssen’s representation of the {\mathbb{H}}-valued Gabor frame operator on {\mathbb{H}}-valued weighted amalgam spaces {W_{\mathbb{H}}(L^{p},L^{q}_{v})}, {1\leq p,q\leq\infty}. Also, we show that the frame operator is invertible on {W_{\mathbb{H}}(L^{p},L^{q}_{v})}, {1\leq p,q\leq\infty}, if the window function is in the Wiener amalgam space {W_{\mathbb{H}}(L^{\infty},L^{1}_{w})}. Further, we obtain the Walnut representation and invertibility of the frame operator corresponding to Gabor superframes and multi-window Gabor frames on {W_{\mathbb{H}}(L^{p},L^{q}_{v})}, {1\leq p,q\leq\infty}, as a special case by choosing the appropriate Hilbert space {\mathbb{H}}.