cerebral protein synthesis
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2021 ◽  
pp. 105485
Author(s):  
Michael Rosenheck ◽  
Carrie Sheeler ◽  
Rachel Michelle Saré ◽  
Mark E. Gurney ◽  
Carolyn Beebe Smith


Author(s):  
R. Michelle Saré ◽  
Anita Torossian ◽  
Michael Rosenheck ◽  
Tianjian Huang ◽  
Carolyn Beebe Smith




SLEEP ◽  
2018 ◽  
Vol 41 (7) ◽  
Author(s):  
Dante Picchioni ◽  
Kathleen C Schmidt ◽  
Kelly K McWhirter ◽  
Inna Loutaev ◽  
Adriana J Pavletic ◽  
...  


2018 ◽  
Vol 39 (9) ◽  
pp. 1849-1863 ◽  
Author(s):  
Giampaolo Tomasi ◽  
Mattia Veronese ◽  
Alessandra Bertoldo ◽  
Carolyn B Smith ◽  
Kathleen C Schmidt

We developed and validated a method to estimate input functions for determination of regional rates of cerebral protein synthesis (rCPS) with L-[1-11C]leucine PET without arterial sampling. The method is based on a population-derived input function (PDIF) approach, with venous samples for calibration. Population input functions were constructed from arterial blood data measured in 25 healthy 18–24-year-old males who underwent L-[1-11C]leucine PET scans while awake. To validate the approach, three additional groups of 18–27-year-old males underwent L-[1-11C]leucine PET scans with both arterial and venous blood sampling: 13 awake healthy volunteers, 10 sedated healthy volunteers, and 5 sedated subjects with fragile X syndrome. Rate constants of the L-[1-11C]leucine kinetic model were estimated voxel-wise with measured arterial input functions and with venous-calibrated PDIFs. Venous plasma leucine measurements were used with venous-calibrated PDIFs for rCPS computation. rCPS determined with PDIFs calibrated with 30–60 min venous samples had small errors (RMSE: 4–9%), and no statistically significant differences were found in any group when compared to rCPS determined with arterial input functions. We conclude that in young adult males, PDIFs calibrated with 30–60 min venous samples can be used in place of arterial input functions for determination of rCPS with L-[1-11C]leucine PET.



PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195580 ◽  
Author(s):  
Giampaolo Tomasi ◽  
Mattia Veronese ◽  
Alessandra Bertoldo ◽  
Carolyn Beebe Smith ◽  
Kathleen C. Schmidt


2018 ◽  
Vol 145 (5) ◽  
pp. 417-425 ◽  
Author(s):  
Rachel Michelle Saré ◽  
Tianjian Huang ◽  
Tom Burlin ◽  
Inna Loutaev ◽  
Carolyn Beebe Smith


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Mattia Veronese ◽  
Alessandra Bertoldo ◽  
Giampaolo Tomasi ◽  
Carolyn Beebe Smith ◽  
Kathleen C. Schmidt


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