Supplemental Material: Late Pleistocene–Holocene flood history, flood-sediment provenance and human imprints from the upper Indus River catchment, Ladakh Himalaya

Figure S1: (A) Infrared Stimulated Luminescence (IRSL) of LD-1818 exhibiting feldspar contamination. (B) IRSL counts of all samples after complete etching including LD-1818 after re-etching. (C) Optical Stimulated Luminescence (OSL) decay curves of all samples; Figure S2: (A) Pre heat test (dotted line represents 220 °C plateau) and (B) Dose recovery test of LD-3170; Figure S3: OSL characteristics of LD-2011. (A) Probably distribution of ED all discs and (B) Sensitivity corrected luminescence growth curve; Figure S4: Radial plot of all OSL samples with ages; Table S1: Elemental, isotopic and age details of detrital zircon U-Pb geochronology of paleoflood deposits.

Supplemental Material: Late Pleistocene–Holocene flood history, flood-sediment provenance and human imprints from the upper Indus River catchment, Ladakh Himalaya

Figure S1: (A) Infrared Stimulated Luminescence (IRSL) of LD-1818 exhibiting feldspar contamination. (B) IRSL counts of all samples after complete etching including LD-1818 after re-etching. (C) Optical Stimulated Luminescence (OSL) decay curves of all samples; Figure S2: (A) Pre heat test (dotted line represents 220 °C plateau) and (B) Dose recovery test of LD-3170; Figure S3: OSL characteristics of LD-2011. (A) Probably distribution of ED all discs and (B) Sensitivity corrected luminescence growth curve; Figure S4: Radial plot of all OSL samples with ages; Table S1: Elemental, isotopic and age details of detrital zircon U-Pb geochronology of paleoflood deposits.

A Meta-Analysis of Efficacy and Safety of Infliximab for Prevention of Postoperative Recurrence in Patients with Crohn’s Disease

Objective. We sought to investigate the efficacy and safety of Infliximab for prevention of postoperative recurrence in patients with Crohn’s disease (CD), in a meta-analysis of clinical trial results. Methods. The Medline, Embase, PubMed, and Web of Science databases were systematically searched for suitable studies. A meta-analysis of enrolled studies was performed to analyze the efficacy of Infliximab on outcomes regarding the prevention of postoperative recurrence of CD. A Galbraith radial plot was used to quantify the heterogeneity. Funnel plot and Egger test were performed to describe the bias of publication. A Forest plot was prepared to indicate the efficacy outcomes. Results. A total of 7 prospective trials were included in our meta-analysis (N=455). The Funnel plot and Egger test showed there was no significant bias in the included publications. The Cochrane collaboration tool indicated that all 7 prospective trials were of high quality. The results of Galbraith radial plot showed that no study was the source of heterogeneity. Compared with the placebo group, Infliximab decreased the rates of endoscopic recurrence (RR =0.421; 95% CI 0.328 to 0.539; p<0.001), and there was a significant reduction in rates of clinical recurrence in the Infliximab-treated group (RR =0.519; 95% CI 0.349 to 0.774; p=0.001). Furthermore, Infliximab treatment did not show adverse effects as other systematic therapeutic drugs, indicating that Infliximab treatment is effective and well tolerated. Conclusion. Compared with the controls, Infliximab is a promising therapeutic agent for the management of CD patients.

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

BackgroundSummary data furnishing a two-sample Mendelian randomization study are often visualized with the aid of a scatter plot, in which single nucleotide polymorphism (SNP)-outcome associations are plotted against the SNP-exposure associations to provide an immediate picture of the causal effect estimate for each individual variant. It is also convenient to overlay the standard inverse variance weighted (IVW) estimate of causal effect as a fitted slope, to see whether an individual SNP provides evidence that supports, or conflicts with, the overall consensus. Unfortunately, the traditional scatter plot is not the most appropriate means to achieve this aim whenever SNP-outcome associations are estimated with varying degrees of precision and this is reflected in the analysis.MethodsWe propose instead to use a small modification of the scatter plot - the Galbraith radial plot - for the presentation of data and results from an MR study, which enjoys many advantages over the original method. On a practical level it removes the need to recode the genetic data and enables a more straightforward detection of outliers and influential data points. Its use extends beyond the purely aesthetic, however, to suggest a more general modelling framework to operate within when conducting an MR study, including a new form of MR-Egger regression.ResultsWe illustrate the methods using data from a two-sample Mendelian randomization study to probe the causal effect of systolic blood pressure on coronary heart disease risk, allowing for the possible effects of pleiotropy. The radial plot is shown to aid the detection of a single outlying variant which is responsible for large differences between IVW and MR-Egger regression estimates. Several additional plots are also proposed for informative data visualisation.ConclusionThe radial plot should be considered in place of the scatter plot for visualising, analysing and interpreting data from a two-sample summary data MR study. Software is provided to help facilitate its use.

016 Characteristic Dimension: A Novel Adjunct to Analyzing Species Composition in Digitized Photos of Turfgrass Plots

Digitized photographic images of turf plots composed of bermudagrass, buffalo grass, tall fescue, and zoysiagrass were taken at a height of about 150 cm with a 28-mm lens. Fast Fourier transforms of these images were performed, and a radial plot of the power spectrum was obtained from each image. Hurst plots (log frequency vs. log intensity) were used to subtract “background” from the power spectra, so peaks would be more evident. The peak of the power spectrum occurs at the average spacing between leaves (more precisely, between areas of the canopy that reflects a significant amount of light) and defines the characteristic dimension. Zoysiagrass had the lowest characteristic dimension, while tall fescue had the highest. The width of the power spectrum is indicative of the variability of the characteristic dimension within the canopy. The minimum characteristic dimension (occurring at the highest frequency) was less than 1.7 cm, whereas all the other species had about the same minimum characteristic dimension of ≈1.9 cm. The maximum characteristic dimension was greatest for fescue (6.9 cm), followed by buffalo grass (3.8 cm), bermudagrass (3.3 cm), and zoysiagrass (2.8 cm). These results indicate that the characteristic dimension can be a useful tool for discriminating between turfgrass species in digitized images.

Spatial Distribution and Color of Dust in Halley’s Inner Coma

Composite images of the intensity of solar radiation scattered by dust in Halley’s coma are constructed by using the three-channel spectra obtained during the approach phase of the Vega 2 spacecraft. They cover a sector centered on the nucleus that has a radius of 40000 km and an angular extent of 50°. A radial plot of dust-scattered intensity shows that it varies as the inverse of impact parameter p where p is smaller than 3200 km or higher than 7000 km. In the intermediate 3200-7000 km distance range, the intensity varies as p−1.52. At longer distances, two jets are present with a contrast comparable to the gas jets which appear in the OH and CN images.The color of dust shows a slight excess of near-UV radiation in a diffuse region between 10000 and 30000 km which appears to be connected with the two jets. In the region called “valley”, between the jets at distances p &gt; 25000 km, the dust-scattered intensity shows an excess of red. The color, expressed as the ratio of intensities at 377,482 and 607 nm is interpreted in terms of Mie theory. It is suggested that the dust particles progressively differentiate. A proportionally more important population of small submicronic grains appears at p &gt; 8000 km. This population seems to correlate with the jets.