Evaluation of OIDx Histoplasma Urinary Antigen EIA

A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

Skull base imaging, anatomy, pathology and protocols

The skull base is the major bony and soft tissue interface for the intracranial and extracranial compartments. Its anatomy is complex, containing multiple traversing foramina that act as conduits for various neurovascular structures. The optimum imaging modality depends on the specific diagnostic question and area of interest; both CT and MR have complementary roles. This article focuses on the applied compartmental anatomy of the skull base and specific imaging protocols, and discusses the range of pathologies that neurologists will encounter.

An Optimum Imaging Scheme for IVUS Arrays: Eccentric Cylinder Wave Compounding

With the development of integrated circuit (IC) technologies, complex transmitting and receiving circuits can be integrated into miniature intravascular ultrasound (IVUS) catheters, making it possible to adopt better synthesizing schemes for better imaging. Eccentric cylinder wave compounding should be an optimum synthesizing scheme for the small size cylinder shaped catheter. Eccentric cylinder waves centered at different points are emitted, signals are collected after each emission, and images can be synthesized with easy post processing. Detailed analyses about resolution and grating lobes were made; the optimum eccentric distance was determined. Simulations were done to examine the resolution, signal-to-noise ratio, and resistance to crosstalk and nonuniformity of arrays. Dual apodization and magnitude-based deconvolution were applied to further improve the results.