Virtual Analysis of Condensed Pyrimidine Derivatives as COX II Inhibitors Potential Anti-inflammatory Agents

Drug design and development is an interactive process includes process like molecular docking which involves virtual analysis of the derivatives against the protein targets. COXS are the groups of enzymes which plays vital role in the human process. COX II is important enzyme involved in the inflammation and can act as potential target for development of the potent anti-inflammatory agents. Pyrimidine is one of the most utilized heterocyclic scaffolds for the development of therapeutic agents due to its role in the nucleic acid and proteins in the human body. The present communication deals with docking analysis of virtually designed 58 condensed pyrimidine derivatives as potential anti-inflammatory agents. The derivatives were designed and virtually screened via molecular docking against the COX-II crystal structure to identically the potential leads.

Exploring Andragogic Strategies in an Interior Architecture Studio

New design andragogical strategies require different interior architecture designs to accommodate a new educational delivery. Hence, learning settings are decreasingly formal timetabled classroom-based and increasingly collaborative and socially peer to peer oriented. The literature review reveals that the most recent comprehensive andragogy is interactive collaborative learning that can be achieved by live projects and vertical studios in interior architecture and across disciplines. The method of research is an exploratory comparative case study in the form of a one-day five hours workshop with aim to assess the outcome of two interior architecture vertical studios in different educational settings (physical and virtual). Analysis of outcome is based on behavior mapping of the students at work, and a qualitative description of their selected setting layout and their opinion on the workshop. In conclusion, a graphical model illustrates the idea that together, andragogical strategies, collaborative activities and supportive educational spaces optimize the educational process.