neuronal primary cultures
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PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
Author(s):  
Dario Greco ◽  
Floriana Volpicelli ◽  
Antonio Di Lieto ◽  
Damiana Leo ◽  
Carla Perrone-Capano ◽  
...  

PLoS ONE ◽  
2009 ◽  
Vol 4 (3) ◽  
pp. e4977 ◽  
Author(s):  
Dario Greco ◽  
Floriana Volpicelli ◽  
Antonio Di Lieto ◽  
Damiana Leo ◽  
Carla Perrone-Capano ◽  
...  

1990 ◽  
Vol 29 (9) ◽  
pp. 799-804 ◽  
Author(s):  
P.S. Eriksson ◽  
Elisabeth Hansson ◽  
L. Ronnback

1990 ◽  
Vol 17 (3) ◽  
pp. 177-181
Author(s):  
Peter S. Eriksson ◽  
Elisabeth Hansson ◽  
Lars Rönnbäck

The presence of μ-opioid receptors was demonstrated as effects of receptor stimulation on PGE1-induced cAMP accumulation in neuronal-enriched primary cultures from rat cerebral cortex. Morphine was used as a μ-receptor agonist. There was a dose-dependent inhibition of the PGE1-stimulated cAMP accumulation by morphine, blocked by the μ-receptor antagonist naloxone. These findings suggest that these neuronal cultures express μ-receptors, possibly connected to adenylate cyclase via an inhibitory Gi-protein. The probable use of functional μ-receptors in neurotoxicological tests is discussed.


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