μ-Opiate Receptors in Neuronal Primary Cultures from Cerebral Cortex
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The presence of μ-opioid receptors was demonstrated as effects of receptor stimulation on PGE1-induced cAMP accumulation in neuronal-enriched primary cultures from rat cerebral cortex. Morphine was used as a μ-receptor agonist. There was a dose-dependent inhibition of the PGE1-stimulated cAMP accumulation by morphine, blocked by the μ-receptor antagonist naloxone. These findings suggest that these neuronal cultures express μ-receptors, possibly connected to adenylate cyclase via an inhibitory Gi-protein. The probable use of functional μ-receptors in neurotoxicological tests is discussed.
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2020 ◽
Vol 21
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2015 ◽
Vol 59
(5)
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pp. 2867-2874
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1986 ◽
Vol 22
(4)
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pp. 443-447
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1980 ◽
Vol 3
(1-6)
◽
pp. 563-573
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