Tris(1H-benzimidazol-2-ylmethyl)amine methanol trisolvate

The structure of the tertiary amine tris(1H-benzimidazol-2-ylmethyl)amine (C24H21N7, abbreviated ntb) has been previously reported twice as solvates, namely the monohydrate and the acetonitrile–methanol–water (1/0.5/1.5) solvate, both with the tripodal conformation formed via multiple hydrogen bonds. Now, we report the trimethanol adduct, ntb·3CH3OH, where the amine has the stair conformation featuring one benzimidazole group oriented in the opposite direction from the other two. The asymmetric unit contains one-half amine, completed through the mirror plane m in space group Pmn21 to form the ntb molecule, with the H atom for each imidazole moiety equally disordered between both N sites available in the imidazole ring. The asymmetric unit also contains one and a half methanol molecules, one being placed in general position with the hydroxy H atom disordered over two sites with occupancy ratio 1:1, while the other lies on the m mirror plane, and has thus its hydroxy H atom disordered by symmetry. As in the previously reported solvates, all imine and amine groups of the ntb molecules and the methanol molecules are involved in N—H...O and O—H...N hydrogen bonds. In the title compound, however, the involved H atom is systematically a disordered H atom provided by an imidazole group or a methanol molecule.

SERPEGINATING DERMATITIS: A CASE OF TISSUE (CUTANEUS) HELMINTHIASIS OR «LARVA MIGRANS SYNDROME»

In connection with the increasing incidence of patients with skin manifestations of helminth infections after visiting endemic zones, dermatovenereologists need to know the skin manifestation of tropical countries diseases. At present, serpeginating dermatitis often causes difficulties in the diagnosis and choice of treatment tactics. Tissue helminthiasis is a skin disease caused by the parasitization of migratory zohelminth larvae, for which a person is an intermediate host. Infection is most often affected by people who come into contact with warm, moist, sandy soil contaminated by dog and cat feces. This article presents a clinical case of a patient with a diagnosis of the skin form of “larva migrans syndrome” treated with two courses of the anthelmintic drug of the benzimidazole group in a daily dose of 800 mg with regressing the dermatological manifestations of the disease within 2 weeks from the start of specific therapy.

SERPEGINATING DERMATITIS: A CASE OF TISSUE (CUTANEUS) HELMINTHIASIS OR «LARVA MIGRANS SYNDROME»

In connection with the increasing incidence of patients with skin manifestations of helminth infections after visiting endemic zones, dermatovenereologists need to know the skin manifestation of tropical countries diseases. At present, serpeginating dermatitis often causes difficulties in the diagnosis and choice of treatment tactics. Tissue helminthiasis is a skin disease caused by the parasitization of migratory zohelminth larvae, for which a person is an intermediate host. Infection is most often affected by people who come into contact with warm, moist, sandy soil contaminated by dog and cat feces. This article presents a clinical case of a patient with a diagnosis of the skin form of “larva migrans syndrome” treated with two courses of the anthelmintic drug of the benzimidazole group in a daily dose of 800 mg with regressing the dermatological manifestations of the disease within 2 weeks from the start of specific therapy.

Effect of anthelmintics upon host organism

To be estimated the effects of anthelmintics to the host, 21 female sheep of various age, breed and weight, which were naturally infected with gastrointestinal nematodes, were used. These animals were divided into three groups and given per os: in the 1st group, which was composed of 7 sheep, Morantel citrate (tetrahydropyrimidine group) approx. 465 mg/b.w., in the 2nd, which was composed of 8 sheep, Albendazole (benzimidazole group) approx. 300 mg/b.w. and in the 3rd, which was composed of 6 sheep, tap water only and this group was used as control. From these animals, blood samples intrajagularly were taken, at the same day, once a week for 9 continuous weeks. The first blood sample was taken 4 weeks before the anthelmintic therapy and the last one 5 weeks after therapy. There were no significance diferences (p> 0,005) in pre- and posttherapy measurements, regarding the PCV,s in all groups. In the control and morantel citrate groups, the leucocyte volume remained static, while contrarily, in the albendazole group a significance difference (p< 0,005) were observed. Because, the albendazole inhibits the construction of intestine cell microtubules of parasites, it can be concluded that, this activity, effects the host cells, and thus, this reduction of leucocytes was observed.

A highly selective TPE-based AIE fluorescent probe is developed for the detection of Ag+

We develop a highly selective TPE-based AIE fluorescent probe containing a benzimidazole group for the detection of Ag+.

Structure of the mercury(II) mixed-halide (Br/Cl) complex of 2,2′-(5-tert-butyl-1,3-phenylene)bis(1-pentyl-1H-benzo[d]imidazole)

The mercury(II) complex of 2,2′-(5-tert-butyl-1,3-phenylene)bis(1-pentyl-1H-benzimidazole), namelycatena-poly[[dihalogenidomercury(II)]-μ-2,2′-(5-tert-butyl-1,3-phenylene)bis(1-pentyl-1H-benzimidazole)-κ2N3:N3′], [HgBr1.52Cl0.48(C34H42N4)],2, has a polymeric structure bridgingviathe N atoms from the benzimidazole moieties of the ligand. The compound crystallizes in the orthorhombic space groupPca21and is a racemic twin [BASF = 0.402 (9)]. The geometry around the HgIIatom is distorted tetrahedral, with the HgIIatom coordinated to two N atoms, one Br atom, and a fourth coordination site is occupied by a mixed halide (Br/Cl). For the two ligands in the asymmetric unit, there is disorder with one of the twotert-butyl groups and benzimidazole moieties showing twofold disorder, with occupancy factors of 0.57 (2):0.43 (2) for thetert-butyl group and 0.73 (3):0.27 (3) for the benzimidazole group. In addition, there is threefold disorder for two of the fourn-pentyl groups, with occupancy factors of 0.669 (4):0.177 (4):0.154 (4) and 0.662 (4):0.224 (4):0.154 (4), respectively. The molecules form a one-dimensional helical polymer propagating in theb-axis direction. The helices are held together by intra-strand C—H...Br and C—H...Cl interactions. Each strand is further linked by inter-strand C—H...Br and C—H...Cl interactions. In addition, there are weak C—H...N inter-strand interactions which further stabilize the structural arrangement.

Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy

Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity.