methylxanthine alkaloids
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2020 ◽  
Vol 38 (2) ◽  
pp. 175
Author(s):  
Yanuartono Yanuartono ◽  
Alfarisa - Nururrozi ◽  
Soedarmanto - Indarjulianto ◽  
Slamet - Raharjo ◽  
Hary - Purnamaningsih ◽  
...  

Chocolate poisoning has long been recognized as a common cause mostly in dogs, although many species are susceptible. Contributing factors include indiscriminate eating habits and readily available sources of chocolate. In general, the poisoning resulted from a lack of public knowledge of the health hazard to dogs that may be imposed by these products.Chocolate is derived from the seeds of the plant Theobroma cacao, and the main toxic components are the methylxanthine alkaloids theobromine and caffeine, causing gastrointestinal, cardiovascular and central nervous signs. Diagnosis is based on history of exposure, along with clinical signs. Amphetamine or cocaine toxicosis, and ingestion of antihistamines, antidepressants, or other CNS stimulants should be considered in the differential diagnosis. Stabilization of symptomatic animals is a priority in treating chocolate toxicosis. Although there is no specific antidote, supportive management includes induction of vomiting and administration of activated charcoal, oxygen, and intravenous fluids. Preventing exposure is the key to reducing the incidence of these poisoning episodes. Therefore, it is important to increase the knowledge of dogs owners with regard to foodstuffs that must not be fed to dogs and should be stored outside their reach.


2015 ◽  
Vol 61 (3) ◽  
pp. 53-66 ◽  
Author(s):  
Zbigniew Sroka ◽  
Maria Janiak ◽  
Andrzej Dryś

Summary Raw materials containing methylxanthine alkaloids such as yerba mate, guaraná, white and green tea, coffee seeds, chocolate and cacao seed powder and extracts obtained from these raw materials were investigated for their antioxidant features and the amount of phenolic compounds. The level of phenolic compounds was measured with the colorimetric method using Folin-Ciocalteu’s phenol reagent and antioxidant features was determined with the use of DPPH (2,2-diphenyl-1-picrylhydrazyl radical). Amounts of phenolic compounds were presented in percentages per mass of extracts and mass of raw materials. Antiradical potential was shown as the number of TAUDPPH units per mg of extracts and g of raw materials. The highest number of antiradical units TAUDPPH as well as the amount of phenolic compounds was calculated for white tea and its extracts and lowest for chocolate. The correlation coefficient between the content of phenolics and antiradical features of raw materials is equal to r=0.994.


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