Bacterial Colonization in Computer Keyboards Posses Health Hazard

Computer keyboards of a teaching laboratory were examined and bacteria were isolated from computer keyboards. The subsequent tests were done for the bacterial isolates: methyl red, vogus proskaur, citrate utilization, urease and TSI. This study paves the way to look at an inanimate object like computer keyboard as potential reservoir of bacteria.

Vibrio gazogenes inhibits aflatoxin production through downregulation of aflatoxin biosynthetic genes in Aspergillus flavus

Aspergillus flavus is an opportunistic pathogen of oilseed crops such as maize, peanut, cottonseed, and tree nuts and produces carcinogenic secondary metabolites known as aflatoxins during seed colonization. Aflatoxin contamination not only reduces the value of the produce but also is a health hazard to humans and animals. Previously, we observed inhibition of A. flavus aflatoxin biosynthesis upon exposure to the marine bacterium, Vibrio gazogenes (Vg). In this study, we used RNA sequencing to examine the transcriptional profiles of A. flavus treated with both live and heat-inactivated dead Vg and control samples. Fungal biomass, total accumulated aflatoxins, and expression profiles of genes constituting secondary metabolite biosynthetic gene clusters were determined at 24, 30, and 40 h after treatment. Statistically significant reductions in total aflatoxins were detected in Vg-treated samples as compared to control samples at 40 h. But no statistical difference in fungal biomass was observed upon these treatments. The Vg treatments were most effective on aflatoxin biosynthesis as was reflected in significant downregulation of majority of the genes in the aflatoxin gene cluster including the aflatoxin pathway regulator gene, aflR. Along with aflatoxin genes, we also observed significant downregulation in some other secondary metabolite gene clusters including cyclopiazonic acid and aflavarin, suggesting that the treatment may inhibit other secondary metabolites as well. Finally, a weighted gene correlation network analysis identified an upregulation of ten genes that were most strongly associated with Vg-dependent aflatoxin inhibition and provide a novel start-point in understanding the mechanisms that result in this phenomenon.

Labor and environment in global value chains: an evolutionary policy study with a three-sector and two-region agent-based macroeconomic model

The world economy crucially depends on multi-layered value chains with high degrees of sector-related specialization. Its final products are of international character and serve the needs and wants of the global citizen. However, many production processes are causing severe damage to the environment and moreover create health hazard for workers and local populations. This research article focuses on the increasing global unequal economic- and ecological exchange, fundamentally embedded in international trade. Resource extraction and labor conditions in the Global South as well as the implications for climate change originating from industry emissions in the North are investigated with an agent-based model. The model serves as a testbed for simulation experiments with evolutionary political economic policies. An international institution is introduced sanctioning the polluting extractivist sector in the Global South as well as the emitting industrial capital good producers in the North with the aim of subsidizing innovation reducing environmental and social impacts. Both regions are modelled as macroeconomic complex adaptive systems where international trade is restricted to a three-sector value chain, originating from mining resources in the South that are traded to capital good producers in the North crafting machinery which is eventually traded to consumer good firms, both in the North and South. The main outcome of the study is that sanctions alone are not effective in countering unequal exchange. They only make a difference in combination with subsidies for innovation activities, which are protecting labor and reducing local pollution in mines as well as reducing carbon-emissions in capital good production.

Zika Virus Prediction Using AI-Driven Technology and Hybrid Optimization Algorithm in Healthcare

The Zika virus presents an extraordinary public health hazard after spreading from Brazil to the Americas. In the absence of credible forecasts of the outbreak's geographic scope and infection frequency, international public health agencies were unable to plan and allocate surveillance resources efficiently. An RNA test will be done on the subjects if they are found to be infected with Zika virus. By training the specified characteristics, the suggested Hybrid Optimization Algorithm such as multilayer perceptron with probabilistic optimization strategy gives forth a greater accuracy rate. The MATLAB program incorporates numerous machine learning algorithms and artificial intelligence methodologies. It reduces forecast time while retaining excellent accuracy. The projected classes are encrypted and sent to patients. The Advanced Encryption Standard (AES) and TRIPLE Data Encryption Standard (TEDS) are combined to make this possible (DES). The experimental outcomes improve the accuracy of patient results communication. Cryptosystem processing acquires minimal timing of 0.15 s with 91.25 percent accuracy.

A Novel Algicidal Bacterium, Microbulbifer sp. YX04, Triggered Oxidative Damage and Autophagic Cell Death in Phaeocystis globosa , Which Causes Harmful Algal Blooms

P. globosa is one of the most notorious harmful algal bloom (HAB)-causing species, which can secrete hemolytic toxins, frequently cause serious ecological pollution, and pose a health hazard to animals and humans. Hence, screening for bacteria with high algicidal activity against P. globosa and studies on the algicidal characteristics and mechanism will contribute to providing an ecofriendly microorganism-controlling agent for preventing the occurrence of algal blooms and reducing the harm of algal blooms to the environment.

COVID-19 Response: The case for Phytomedicines in Africa with particular focus on Cameroon

Despite enormous efforts deployed and considerable positive results obtained in the global fight against the Coronavirus disease 2019 (COVID-19) the scourge remains a major international public health hazard. The main control measures at the onset consisted in the application of barrier and hygiene measures to stop the spread of the virus and case identification and clinical management of symptoms in the absence of widely available anti-COVOD-19 drugs. Vaccination as a major control measure became widely available in the advanced countries of the global north, but not in Africa where less than 5-10% 0f the population are vaccinated against COVID-19. However, African countries, possibly excluding South Africa, have been less impacted by COVID-19 pandemic as they registered fewer cases, hospitalizations and deaths. Herein it is postulated that the wide use of African traditional Phytomedicines (herbal medicines) has contributed, at least in part, to the better control of the COVID-19 pandemic in Africa. Abundant evidence in the literature suggests the availability of anti-viral, anti-oxidant and immune-stimulatory agents in the proposed COVID-19 herbal remedies., these activities being similar to those the standard drugs used in the standard treatment/ management of COVID-19. The review also examines a number of COVID-19 herbal medicines including COVID Organics CVO (Madagascar) ADSAR, ELISIR COVID, COROCUR (Cameroon) IHP Detox Tea (Nigeria) and COVIDEX (Uganda) and notes that though approved by the competent authorities in the respective African countries, these phytomedicines have not been approved by the WHO. It is proposed that additional studies be carried out to validate the Africa herbal remedies for possible use as stand-alone or complementary treatment of COVID-19 in addition to vaccination and barrier and hygiene control measures.

Evaluation Data of Dried Vegetables and Fruits

Drying is the process of removing of the water that has destroying effect in food products by evaporation and. Research project on the basis of direct sun drying and solar greenhouse. Basic operations research in food engineering, food chemistry, food quality control and toxicology has been established over such a broad spectrum. Subjects of investigation were in accordance with all of the values of dry matter basis. The study of dry matter and water activity values of each product (aw), direct sun drying, drying in the greenhouse. It was determined comparing nutrients of samples those were applied directly to the greenhouse and drying in the sun. Sampling patterns of research were explained as follow; tomatoes drying in the sun (external environment), and greenhouse, bell peppers in the greenhouse and drying in the sun, soaked raisins (sultanas) and not-soaked (raisin), sun-dried, sun-dried fig products directly. Nutrients of the samples such as; lycopene, thiamine (B1), riboflavin (B2), retinol (A), Pyridoxine (B6), ascorbic acid (C), folic acid, magnesium (Mg), potassium (K), sodium (Na), phosphorus (P), zinc (Zn), iron (Fe), copper (Cu) were quantitatively determined. The red pepper products, dried figs and dried grapes mycotoxin amounts were in safe levels, which had not created any hazard and risk for health. Red pepper and dried figs, total aflatoxins, (B1, B2, G1, G2), ochratoxin A (OTA) levels in raisin in the European Union is set well below the limits in terms of human health hazard and the risk factor has been identified.

Citizen-science surveillance of triazole-resistant Aspergillus fumigatus in UK residential garden soils

Compost is an ecological niche for Aspergillus fumigatus due to its role as a decomposer of organic matter and its ability to survive the high temperatures associated with the composting process. Subsequently, composting facilities are associated with high levels of A. fumigatus spores that are aerosolised from compost and cause respiratory illness in workers. In the UK, gardening is an activity enjoyed by individuals of all ages and it is likely that they are being exposed to A. fumigatus spores when handling commercial compost or compost they have produced themselves. In this study, 246 citizen scientists collected 509 soil samples from locations in their garden in the UK, from which were cultured 5,174 A. fumigatus isolates. Of these isolates, 736 (14%) were resistant to tebuconazole: the third most-sprayed triazole fungicide in the UK, which confers cross-resistance to the medical triazoles used to treat A. fumigatus lung infections in humans. These isolates were found to contain the common resistance mechanisms in the A. fumigatus cyp51A gene TR 34 /L98H or TR 46 /Y121F/T289A, and less common resistance mechanisms TR 34 , TR 53 , TR 46 /Y121F/T289A/S363P/I364V/G448S and (TR 46 ) 2 /Y121F/M172I/T289A/G448S. Regression analyses found that soil samples containing compost were significantly more likely to grow susceptible and tebuconazole-resistant A. fumigatus than those that did not, and that compost samples grew significantly higher numbers of A. fumigatus than other samples. Importance These findings highlight compost as a potential health hazard to individuals with pre-disposing factors to A. fumigatus lung infections, and a potential health hazard to immunocompetent individuals who could be exposed to sufficiently high numbers of spores to develop infection. Furthermore, this study found that 14% of A. fumigatus isolates in garden soils were resistant to an agricultural triazole, which confers cross-resistance to medical triazoles used to treat A. fumigatus lung infections. This raises the question of whether compost bags should carry additional health warnings regarding inhalation of A. fumigatus spores, whether individuals should be advised to wear facemasks whilst handling compost or whether commercial producers should be responsible for sterilising compost before shipping. The findings support increasing public awareness of the hazard posed by compost and investigating measures that can be taken to reduce the exposure risk.

In-Utero Neurotoxicity of Nanoparticles

The unique physicochemical properties of nanoparticles (NPs) make them widely used in cosmetics, medicines, food additives, and antibacterial and antiviral compounds. NPs are also used in therapy and diagnostic applications. Depending on their origin, the NPs are commonly classified as naturally occurring and synthetic or anthropogenic NPs. Naturally occurring nanoparticles can be formed by many physical, chemical, and biological processes occurring in all spheres of the earth. However, synthetic NPs are specifically designed or unintentionally produced by different human activities. Owing to their nano size and special properties, the engineered NPs can enter the human body through different routes such as dermal penetration, intravenous injection and inhalation. NPs may accumulate in various tissues and organs including the brain. Indiscriminate use of NP is a matter concern due to the dangers of NP exposure to living organisms. It is possible for NPs to cross the placental barrier, and adversely affect the developing fetus, posing a health hazard in them by causing neurodevelopmental toxicity. Thus, NP-induced neurotoxicity is a topic that demands attention at the maternal-fetal interface. This chapter summarizes the routes by which NPs circumvent the blood-brain barrier, including recent investigations about NPs’ neurotoxicity as well as possible mechanisms involved in neural fetotoxicity.