666Impact of local left atrial wall thickness on the incidence of acute pulmonary vein reconnection after ablation index-guided ablation

Background/Introduction Pulmonary vein reconnection is considered a major determinant of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Ablation Index (AI)-guided ablation allows for the creation of ablation lesions of consistent depth and may reduce the incidence of pulmonary vein reconnection after PVI. However, anatomical and imaging studies have demonstrated an important inter- and intra-patient variability of left atrial wall thickness, which can result in non-transmural ablation lesion formation in thicker segments. Purpose The present study aimed to investigate the impact of local left atrial wall thickness on the incidence of acute pulmonary vein reconnection after AI-guided AF ablation. Methods Consecutive AF patients who underwent cardiac computed tomography (CT) imaging prior to AI-guided ablation between December 2017 and September 2019 were studied. AI targets were 500 for anterior/roof and 380 for posterior/inferior segments with a maximum interlesion distance of 6 mm. Occurrence of acute pulmonary vein reconnection after initial PVI was assessed after a 30-minute waiting period. Ablation procedures were analysed offline to determine minimum AI, force-time integral, contact force, ablation duration, power, impedance drop and maximum interlesion distance for each segment according to a 16-segment model. Pulmonary vein antrum wall thickness was assessed for each segment on reconstructed CT images based on patient-specific thresholds in Hounsfield Units, using a previously described method. Results Seventy patients (63% paroxysmal AF, 67% male, mean age 63 ± 8 years) who underwent preprocedural CT imaging and AI-guided AF ablation were studied. Acute reconnection (AR) occurred in 27/1152 segments (2%, 15 anterior/roof, 12 posterior/inferior) in 17/70 (24%) patients. Anterior/roof segments were thicker than posterior/inferior segments (1.48 [1.23-1.80] vs. 1.13 [1.00-1.30] mm; p < 0.01). Reconnected segments were characterised by a greater local atrial wall thickness, both in anterior/roof (1.83 [1.60-2.00] vs. 1.47 [1.20-1.80] mm; p < 0.01) and posterior/inferior (1.38 [1.25-1.50] vs. 1.13 [1.00-1.27] mm; p < 0.01) segments (Figure 1). Minimum AI, force-time integral, contact force, ablation duration, power, impedance drop and maximum interlesion distance were not associated with acute pulmonary vein reconnection. Conclusion Local atrial wall thickness is associated with acute pulmonary vein reconnection after AI-guided PVI. Individualised AI targets based on local wall thickness may be of use to create transmural ablation lesions and prevent pulmonary vein reconnection after PVI. Abstract Figure. Impact of wall thickness on reconnection