high performance computation
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2021 ◽  
Vol 3 (3) ◽  
pp. 135-148
Author(s):  
Nayana Shetty

For the purpose of high performance computation, several machines are developed at an exascale level. These machines can perform at least one exaflop calculations per second, which corresponds to a billion billon or 108. The universe and nature can be understood in a better manner while addressing certain challenging computational issues by using these machines. However, certain obstacles are faced by these machines. As huge quantity of components is encompassed in the exascale machines, frequent failure may be experienced and also the resilience may be challenging. High progress rate must be maintained for the applications by incorporating certain form of fault tolerance in the system. Power management has to be performed by incorporating the system in a parallel manner. All layers inclusive of fault tolerance layer must adhere to the power limitation in the system. Huge energy bills may be expected on installation of exascale machines due to the high power consumption. For various fault tolerance models, the energy profile must be analyzed. Parallel recovery, message-logging, and restart or checkpoint fault tolerance models for rollback recovery are evaluated in this paper. For execution with failure, the most energy efficient solution is provided by parallel recovery when programs with various programming models are used. The execution is performed faster with parallel recovery when compared to the other techniques. An analytical model is used for exploring these models and their behavior at extreme scales.


Science ◽  
2021 ◽  
Vol 371 (6532) ◽  
pp. 948-952 ◽  
Author(s):  
Kyungduk Kim ◽  
Stefan Bittner ◽  
Yongquan Zeng ◽  
Stefano Guazzotti ◽  
Ortwin Hess ◽  
...  

Random numbers are widely used for information security, cryptography, stochastic modeling, and quantum simulations. Key technical challenges for physical random number generation are speed and scalability. We demonstrate a method for ultrafast generation of hundreds of random bit streams in parallel with a single laser diode. Spatiotemporal interference of many lasing modes in a specially designed cavity is introduced as a scheme for greatly accelerated random bit generation. Spontaneous emission, caused by quantum fluctuations, produces stochastic noise that makes the bit streams unpredictable. We achieve a total bit rate of 250 terabits per second with off-line postprocessing, which is more than two orders of magnitude higher than the current postprocessing record. Our approach is robust, compact, and energy-efficient, with potential applications in secure communication and high-performance computation.


2021 ◽  
Vol 42 (4) ◽  
pp. 1636-1655
Author(s):  
Feng Wu ◽  
Kailing Zhang ◽  
Li Zhu ◽  
Jiayao Hu

2020 ◽  
Author(s):  
Michael J Tisza ◽  
Anna K Belford ◽  
Guillermo Dominguez-Huerta ◽  
Benjamin Bolduc ◽  
Christopher B Buck

Abstract Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as “hypothetical protein” or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface with free high-performance computation access, utilizes highly sensitive models of hallmark virus genes to discover familiar or divergent viral sequences from user-input contigs. Additionally, Cenote-Taker 2 uses a flexible set of modules to automatically annotate the sequence features of contigs, providing more gene information than comparable tools. The outputs include readable and interactive genome maps, virome summary tables, and files that can be directly submitted to GenBank. We expect Cenote-Taker 2 to facilitate virus discovery, annotation, and expansion of the known virome.


Author(s):  
Michael J. Tisza ◽  
Anna K. Belford ◽  
Guillermo Dominguez-Huerta ◽  
Benjamin Bolduc ◽  
Matthew B. Sullivan ◽  
...  

AbstractViruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as “hypothetical protein” or the equivalent. Cenote-Taker2, a virus discovery and annotation tool available on command line and with a graphical user interface with free high-performance computation access, utilizes highly sensitive models of hallmark virus genes to discover familiar or divergent viral sequences from user-input contigs. Additionally, Cenote-Taker2 uses a flexible set of modules to automatically annotate the sequence features of contigs, providing more gene information than comparable tools. The outputs include readable and interactive genome maps, virome summary tables, and files that can be directly submitted to GenBank. We expect Cenote-Taker2 to facilitate virus discovery, annotation, and expansion of the known virome.


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