Er3+-Ions-Doped Multiscale Nanoprobes for Fluorescence Imaging in Cellular and Living Mice

With the development of biotechnology, luminescent nanoprobes for biological disease detection are widely used. However, the further application in clinic is limited by the reduced penetration depth in the tissues and light scattering. In this work, we have synthesized NaYF4:Yb,Er,Ce@SiO2-OAlg nanomaterials, which have both upconversion and near-infrared (NIR) luminescence. The optimized probes were determined to achieve cell imaging by its upconversion (UCL) luminescence and in vivo imaging through collection of NIR fluorescence signals simultaneously. The research is conducive to developing accurate diagnostic techniques based on UCL and NIR fluorescence imaging by a single nanoparticle.

Field-Induced SMM and Vis/NIR Luminescence on Mononuclear Lanthanide Complexes with 9-Anthracenecarboxylate and 2,2′:6,2″-Terpyridine

Five new mononuclear lanthanide complexes are synthesized by adding the several lanthanide nitrate hexahydrate salts, which for lanthanide (Ln) are Eu, Tb, Dy, Er, and Yb, with 9-anthracenecarboxylic acid (9-Hanthc) and 2,2′:6,2″-terpyridine (TPY) in mixed solution of methanol and dimethylformamide (DMF). The general formula is [Eu(9-anthc)3(TPY)(DMF)]·H2O (1Eu) where Eu(III) is ennea-coordinated or [Ln(9-anthc)3(TPY)(H2O)]·H2O·DMF (Ln = Tb (2Tb), Dy (3Dy), Er (4Er), and Yb (5Yb)) where Ln(III) is octa-coordinated. For compounds 3Dy, 4Er, and 5Yb, the dynamic ac magnetic study indicated field-induced single molecule magnet (SMM) behavior. The photoluminescence studies in the solid state of these complexes show the sensitization of 4f-4f transitions for 4Er and 5Yb in the NIR region.