Factor structure and stability of a quality questionnaire within a postgraduate program

<p>In this work we describe an instrument based on the use of a factor analysis technique in order to measure the quality of education within a Postgraduate degree offered by a public Spanish university. We showed that the instrument has satisfactory psychometric properties (reliability and validity). Regarding the factorial solution, three main dimensions have been determined, namely: importance given to the subject; educational resources and knowledge of the subject (previous and posterior). It is important to remark that these three dimensions were consistently detected in all the factorial analyses performed (total sample and separate academic years). These three dimensions should be considered as fundamental when designing an instrument to evaluate educational quality. These findings may be taken as a basis for the design of future strategies for the evaluation of educational quality on other type of degrees within the higher education area.</p>

A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms

This review summarizes the methods used to study real-time (37°C) drug release from nanoparticulate drug delivery systems and establish an IVIVC. Since no compendial standards exist, drug release is currently assessed using a variety of methods including sample and separate (SS), continuous flow (CF), dialysis membrane (DM) methods, and a combination thereof, as well as novel techniques like voltametry and turbidimetry. This review describes the principle of each method along with their advantages and disadvantages, including challenges with set-up and sampling. The SS method allows direct measurement of drug release with simple set-up requirements, but sampling is cumbersome. With the CF method, sampling is straightforward but the set-up is time consuming. Set-up as well as sampling is easier with the DM, but it may not be suitable for drugs that bind to the membrane. Novel methods offer the possibility of real-time drug release measurement but may be restricted to certain types of drugs. Of these methods, Level A IVIVCs have been obtained with dialysis, alone or in combination with the sample and separate technique. Future efforts should focus on developing mathematical models that describe drug release mechanisms as well as facilitate formulation development of nano-sized dosage forms.