In a search for pairs of quantum systems linked by dynamical symmetries, we give a systematic analysis of novel extensions of standard one-dimensional supersymmetric quantum mechanics. The most general supercharges involving higher order derivatives are introduced, leading to an algebra which incorporates a higher order polynomial of the Hamiltonian. We investigate the condition for irreducibility of such a higher order generator to a product of standard first derivative Darboux transformations. As a new example of application of this approach we study the quantum-mechanical radial problem including the scattering amplitudes. We also investigate the links between this higher derivative SUSY and a q-deformed supersymmetric quantum mechanics and introduce the notion of self-similarity in momentum space. An explicit model for the scattering amplitude is constructed in terms of a hypergeometric function which corresponds to a reflectionless potential with infinitely many bound states.