Technological Advancements in Monoclonal Antibodies

Biopharmaceuticals are innovative solutions that have revolutionized the treatment of important chronic diseases and malignancies. The approval of biosimilar products has become a complex and balanced process, and there are versions of drugs with established biosimilarity that can offer a more accessible treatment option to patients. The objective of this work was to identify the advancement of these technologies by means of patent and article analysis based on technological and scientific prospection. In patent document recovery, Derwent Innovation Index (DWPI) and PatentInspiration databases were used. The research was based on the search of the selected terms in the title, summary, and claims of the documents through a search strategy containing IPC code and keywords. In articles recovery, the Web of Science tool was used in the search of scientific publications dated from the last 5 years. The search resulted in a total of 2295 individual patent documents and 467 families using DWPI database, 769 individual patents and 205 families using PatentInspiration, and 2602 articles using Web of Science database. Additionally, this work describes the number of organizations that contribute to this area, where they are, how much development they have undergone, and the inventors/authors involved. Based on the number of publications registered, there is an important prominence for scientific research in mAbs. In terms of innovation, it is expected that several therapeutic drugs are already under regulatory review, which will allow drugs to be approved over the next few years and will thus generate a continuous flow of new products based on immunotherapies, mAbs, and biosimilar drugs. These drugs have become essential weapons for the treatment of significant diseases, and the increasing trend in the number of related scientific and technological publications contributes to making these therapies available to the greatest number of people.

Collaboration network, technology network and technological development: a patent analysis in the Chinese green technological field of energy saving

Purpose This paper aims to forecast the future development of UIC technology according to the changes of IPC in different time periods. The findings also provide a theoretical basis for the UIC policymakers of energy-saving environmental protection industry. Design/methodology/approach The present study will take energy-saving technology as an example, through using a two-mode network analysis method to build the four-stage IPC code UIC innovation-technology network, researching UIC innovation network applicant heterogeneity, UIC technology network and technology relevance. Findings Through the establishment of UIC innovation-technology two-mode network, namely, applicant node CN and IPC node TN, this paper analyzes the important applicants, focal technologies, correlation of focal technologies and the development trends of energy saving technology in the future by using the related theories and methods of two-mode network. Originality/value At present, only about 11% of energy-saving enterprises in China have R&D activities. The government needs to implement top-level design, improve industrial policies, strengthen investment in technology R&D and build a platform for technological innovation in energy-saving industries to support the R&D of common and key technologies in energy-saving industries.