Efficient Synthesis of Tetra- and Penta-substituted Benzenes via Domino Cycloaddition Reaction of pyridinium ylide and Chalcone o-Enolate

A very simple and high efficient synthetic protocol for tetra- and penta-substituted benzene derivatives has been provided by tetramethylguanidine (TMD) promoted reaction of 4-(N,N-dimethylamino)-1-phenacyl-pyridinium bromide with chalcone o-enolates in DMF...

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

A series of sulfonyl dihydrofuropyrazole derivatives was prepared from one pot multi component condensation of sulfonated β-keto ester, aromatic aldehyde, hydrazine, pyridinium ylide in presence of piperidine catalyst under ethanol solvent conditions and subsequent oxidation of SPh group with MCPBA. All the synthesized compounds were characterized by analytical and spectral techniques and screened in vitro for antimicrobial activity. The activity data revealed that most of the compounds exhibited good to significant activities. Compounds 6b, 6i, 6j, 6k, 6m, 6n exhibited good and broad spectrum activity towards all the tested bacterial strains.

Synthesis of Trans-Dihydroindeno[1,2-b]Furans via Nano γ-Fe2O3-Quinuclidine-Based Catalyst in an Aqueous Medium

The synthesis of a series of 13 multifunctionalised dihydroindeno[1,2-b]furans was achieved in a diastereoselective manner in excellent yield by reacting 1,3-indanedione, an aryl glyoxal and a pyridinium ylide in the presence of a nano γ-Fe2O3-quinuclidine-based catalyst in an aqueous medium.