Background:
In this work, a novel and extra sensitive blood sample determination method
for on-line monitoring of Daptomycin is represented.
Materials and Methods:
This technique is in accordance with the electro-membrane extraction (EME)
and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the
potential waveform had become constantly utilized over a Gold Electrode and the electrode impulse
was acquired by taking away the base current and developing the current in the particular potential area
of oxidation of sample.
Results:
This method was performed by utilizing a DC potential and migration of Daptomycin from the
analyte fluid to the layer of 4-methyl-2-pentanol as well as following migration to the acceptor fluid.
Conclusion:
A low and valuable detection limit of 3.5 ng ml-1 and quantification limit of 10.2 ng ml-1
are considered as a part of the sensible results of this experiment. Furthermore, efficient linearity in the
range of 10.0-600 ng ml-1 was observed.
