The article describes slurry and drainage water’s characteristics and shows the conditions of their formation in the technogenic system of the Komsomolsky Tin-ore District, Russian Far East. The investigation was conducted using environmental monitoring, and the physico-chemical modeling method. In a wide ambient temperature range (from minus 25 to 45 °C) the Eh-pH parameters of micropore solutions, which form technogenic (anthropogenic) waters at various host-rock—sulfide ratios (95:5, 50:50, 5:95), were determined. Depends on the primary ores and host rocks composition ionic and molecular composition of technogenic waters, as well as the association of crystallized hypergene minerals were established. The negative impact of slurry and drainage water on the hydrosphere and the health of the region’s population is shown. Following environmental monitoring, the content of dissolved metals exceeds background concentrations in slurry and drainage waters from hundreds to hundreds of thousand times. Modeling reveals, that from saturated technogenic waters, Fe, Cu, Zn, Pb, Al, Ca, Mg, K, and Na oxides and hydroxides, sulfates, carbonates, arsenates, phosphates, and silicate minerals are precipitates. The tendency of double growth for 24 types of digestive, respiratory, and nervous system diseases during a 20-years period has been noted, moreover, children morbidity rate exceeds that of adults.