calcium gating
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2020 ◽  
Vol 118 (3) ◽  
pp. 583a
Author(s):  
Chen Fan ◽  
Nattakan Sukomon ◽  
Jan Rheinberger ◽  
Crina M. Nimigean


2020 ◽  
Vol 142 (6) ◽  
pp. 2925-2934 ◽  
Author(s):  
Kabin Lin ◽  
Chih-Yuan Lin ◽  
Jake W. Polster ◽  
Yunfei Chen ◽  
Zuzanna S. Siwy


2018 ◽  
Vol 115 (7) ◽  
pp. E1667-E1674 ◽  
Author(s):  
Wenlei Ye ◽  
Tina W. Han ◽  
Layla M. Nassar ◽  
Mario Zubia ◽  
Yuh Nung Jan ◽  
...  

TMEM16F, which is activated by elevation of intracellular calcium to trigger phospholipid scrambling and the collapse of lipid bilayer asymmetry to mediate important cellular functions such as blood coagulation, also generates a small-conductance calcium-activated cation current. How TMEM16F activation may be regulated is an open question. By recording TMEM16F Ca2+-activated current, we found that the TMEM16F Ca2+-response is desensitized by a brief exposure to high intracellular Ca2+, which is associated with depletion of phosphatidylinositol-(4, 5)-bisphosphate (PIP2) from the inner leaflet of the membrane. Application of artificial or natural PIP2 restores TMEM16F channel activity. PIP2 modulation of TMEM16F requires the presence of several positively charged amino acids in its cytoplasmic N-terminal domain. TMEM16F interaction with PIP2 works synergistically with membrane depolarization to facilitate Ca2+-gating of TMEM16F. Our study reveals the dependence of TMEM16F activity on phosphoinositides and provides one mechanism for TMEM16F activation to be strictly regulated in the cell membrane.



2010 ◽  
Vol 394 (4) ◽  
pp. 909-914 ◽  
Author(s):  
Alessandro Terrinoni ◽  
Andrea Codispoti ◽  
Valeria Serra ◽  
Biagio Didona ◽  
Ernesto Bruno ◽  
...  


2010 ◽  
Vol 98 (3) ◽  
pp. 384a
Author(s):  
Montserrat Samso
Keyword(s):  


Nature ◽  
10.1038/26758 ◽  
1998 ◽  
Vol 395 (6701) ◽  
pp. 503-507 ◽  
Author(s):  
X.-M. Xia ◽  
B. Fakler ◽  
A. Rivard ◽  
G. Wayman ◽  
T. Johnson-Pais ◽  
...  


1993 ◽  
Vol 25 (5) ◽  
pp. 557-567 ◽  
Author(s):  
Dennis C. Wooten ◽  
Richard A. Dilley


1991 ◽  
Author(s):  
R.A. Dilley
Keyword(s):  


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