PHASE: A MATLAB Based Program for the Analysis of Drosophila Phase, Activity, and Sleep under Entrainment

The problem of entrainment is central to circadian biology. In this regard, Drosophila has been an important model system. Owing to the simplicity of its nervous system and the availability of powerful genetic tools, the system has shed significant light on the molecular and neural underpinnings of entrainment. However, much remains to be learned regarding the molecular and physiological mechanisms underlying this important phenomenon. Under cyclic light/dark conditions, Drosophila melanogaster displays crepuscular patterns of locomotor activity with one peak anticipating dawn and the other anticipating dusk. These peaks are characterized through an estimation of their phase relative to the environmental light cycle and the extent of their anticipation of light transitions. In Drosophila chronobiology, estimations of phases are often subjective, and anticipation indices vary significantly between studies. Though there is increasing interest in building flexible analysis software tools in the field, none incorporates objective measures of Drosophila activity peaks in combination with the analysis of fly activity/sleep in the same program. To this end, we have developed PHASE, a MATLAB-based program that is simple and easy to use and (i) supports the visualization and analysis of activity and sleep under entrainment, (ii) allows analysis of both activity and sleep parameters within user-defined windows within a diurnal cycle, (iii) uses a smoothing filter for the objective identification of peaks of activity (and therefore can be used to quantitatively characterize them), and (iv) offers a series of analyses for the assessment of behavioral anticipation of environmental transitions.

Motor function of the gastrointestinal tract in gastric erosions

The aim is to study motor disorders of the gastrointestinal tract and biliary tract with erosion of the stomach. Materials and methods. Electromyography (EMG) of the gastrointestinal tract and biliary tract was performed in 35 patients with gastric erosions; the control group consisted of 10 patients with gastric ulcer. A morphological study of biopsies of the antrum of the stomach was carried out. Results. Patients with erosion of the stomach were characterized by severe hypermotor dyskinesia of the stomach with a decrease in the motor function of the small intestine and multidirectional changes in the motor function of the colon. Motility of the biliary tract is characterized by an increase in tonic activity with a slight increase in phase activity. Histological examination revealed areas of fibrinoid necrosis in its own plate and foci of destruction of the end sections of the pyloric glands. Conclusion. Motor function of patients with gastric erosion is characterized by a greater power of muscle contractions of the stomach, a smaller power of muscle contractions of the small intestine and multidirectional changes of the power contractions of various sections of the colon.

Advances in Stroke

Stroke recovery therapies promote favorable neural plasticity, both during spontaneous recovery and the chronic phase. Activity-based therapies based on intense practice, some aided by integration of computers and telehealth, have shown promise. These studies emphasize key therapeutic variables such as dose, intensity, and timing. Preclinical drug studies have shown promise, but human translation has been challenged by identifying the target patient subgroup, requirements for concomitant training, and aligning biomarkers with preclinical evidence.

Determining of reservoir fluids properties using PVTP simulation software- a case study of buzurgan oilfield

The measurement of oil reservoirs and their performance with hydrocarbon reservoirs is used to distinguish the properties of reservoir fluids, which is significant in various reservoir studies. As a result, in the various oil industries, adopting the appropriate methods to obtain accurate property values is very important. The current paper is about a case study of the BUZURGAN Oilfield and how the PVTp software was used to predict phase activity and physical properties. To understand the properties of fluids for the reservoir and phase behavior, the black oil model and the equation of state (EoS) model are used. (Glaso) correlation is used to calculate the bubble point strain, solubility, and formation volume factor. The Beal's correlation was also used to measure viscosity, while the equation of state (EoS) model was used to determine phase behavior and density. Furthermore, the properties of PVT were discovered using the software, and the results were compared to laboratory analysis of PVT, with suitable models being displayed. According to the findings, the used model has the highest saturation pressure, which was chosen for use in reservoir management processes and the preparation of a geological model to reflect the field later. It is clear that the program is appropriate due to the accurate dependence of PVT measurements on laboratory tests in the case that tests are required during the reservoir's productive existence.