Effect of exposure to etidronic acid on the bond strength of calcium silicate-based cements after 1 and 21 days: an in vitro study

Background After reparation of root perforations with calcium silicate-based cements (CSBC), the surface of the material is expected to be exposed to root canal irrigants (RCI) while resuming the root canal treatment. Methods The aim of this study was to compare the effect of exposure to a mixture of sodium hypochlorite (NaOCl) and etidronic acid (HEBP) or other irrigants on the Push Out Bond Strength (POBS) of CSBC after two different setting times. 240 root slices 1 mm thick were obtained from single-rooted human teeth. A 1.4 mm diameter perforation was performed on each slice and filled with Biodentine (BD) or ProRoot MTA (PMTA). After 1 or 21 days they were exposed to 17% ethylenediaminetetraacetic acid, 5.25% NaOCl, a mixture of 5.25% NaOCl and 9% HEBP (NaOCl + HEBP) or saline (n = 15) and submitted to a push-out test. POBS results were analysed with ANOVA and Tukey tests. Results BD showed higher POBS than PMTA after 1 day (p < .05). After 21 days no differences were found between materials. After 1 day exposure to NaOCl + HEBP resulted in higher POBS, compared to the other irrigants (p < .05). Conclusion POBS results are influenced by the cement, the setting time and the exposure to irrigants.

Dysfunction of calcium regulating system in comorbidity of peptic ulcer disease and osteoporosis and its correction

The comorbidity of various diseases requires the use of drugs that affect common etiological and pathogenetic aspects, which reduces polypharmacy and the risk of side-effect.Purpose of the study. Find out the state of calcium regulating system, calcium-phosphorus balance in the comorbidity of ulcer disease (UD) with osteoporosis (OP), and the effect of their shifts on the acid secretion and regional microcirculation. To determine the effectiveness of bisphosphonates in the complex treatment of these pathologies.Materials and methods. We examined 77 people with recurrent UD, 10 of whom revealed its comorbidity with OP. All patients underwent clinical and endoscopic studies, pH-metry, X-ray densitometry. The levels of parathyroid hormone, calcitonin, calcium and phosphorus in the blood were studiedResults. Recurrent of ulcer was characterized by a increase in para- thyroid hormone and calcium, a decrease in blood phosphorus. These changes were more pronounced in patients with a comorbidity of UD with OP and were accompanied by an increase in acid secretion and regional microcirculation. The use of etidronic acid in the treatment UD was characterized by a positive clinical result, normalization of secretion and regional microcirculation.Conclusion. The comorbidity of UD with OP is accompanied by functional changes in calcium regulating system. Correction of these changes with the use of bisphosphonates in the treatment of relapse of ulcer demonstrates clinical efficacy.