In the following article the info is given on the means of the transport used in the caravan routes in the trade-economic relations of khanate of Bukhara with neighboring countries in medieval times. Included there, the starting of domestication and usage of horse drawn vehicles, camels, donkeys and others, the capacity of daily load of camels, horses, donkeys which were core of caravans, their daily distance, the necessary tasks in the incidents occurred in caravan routes (injuries, bruises, contagious diseases) the stopping regulation of caravans (sand storm, in heat and frost) is thoroughly analyzed.