The Community of Inquiry framework provides a three-fold and multi-faceted way to consider effectiveness within an online, digital, and/or blended course setting. A broader understanding of online learning as social and interactive (e.g., Anderson & Elloumi, 2004) provides a theoretical grounding to understand the CoI framework for both course design as well as research. This chapter also describes key ideas that will be discussed in later chapters, including an overview of the Community of Inquiry framework, an overview of big data, learning analytics, predictive analytics, computational linguistics, social network analysis, and other conceptual ideas that foster analysis of online learners in large course settings or across programs. The authors offer a current understanding of the overall extant literature on the CoI framework as it relates to the key ideas since its conception around the year 2000. Additional readings are provided.