Long-term follow-up of patients with undiagnosed fever of unknown origin

1996 ◽  
Vol 156 (6) ◽  
pp. 618-620 ◽  
Author(s):  
D. C. Knockaert
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Long Term Follow Up

Behcet Disease: Long-term Follow-up of Three Children and Review of the Literature

PEDIATRICS ◽  
1989 ◽  
Vol 83 (6) ◽  
pp. 986-992
Author(s):  
Yardena Rakover ◽  
Hanna Adar ◽  
Itamar Tal ◽  
Yaron Lang ◽  
Amos Kedar
Keyword(s):  
Fever Of Unknown Origin ◽  
Age Of Onset ◽  
Unknown Origin ◽  
Behçet Disease ◽  
Behcet Disease ◽  
Cns Involvement ◽  
Course Of Illness ◽  
Long Term Follow Up

Behcet disease is rare in children. There are only two reports of Behcet disease in childhood, describing seven patients. Three pediatric patients are described, in whom the age of onset ranged from 6 to 11 years. Aphthous stomatitis and arthritis were present in all of the patients; genital ulcers, iridocylitis, erythema nodosum, and CNS involvement were present in two patients. Other manifestations included Stevens-Johnson-like eruption, fever of unknown origin, and testicular involvement. All of the patients responded to glucocorticoids; two were also treated with colchicine and one was treated with chlorambucil. In two patients, follow-up of more than 10 years was done, with complete cure in one patient and benign course of illness in the other. Because of the rarity of the disease in childhood and the difficulty in making the diagnosis, there is not enough awareness by pediatricians concerning this disease.

Long-Term Follow-up of Children with Fever of Unknown Origin

2000 ◽  
Vol 39 (12) ◽  
pp. 715-717 ◽  
Author(s):  
Julie-An M. Talano ◽  
Ben Z. Katz
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Long Term Follow Up

Papillary Tumors of the Pineal Region: Case Report

Neurosurgery ◽  
2007 ◽  
Vol 60 (5) ◽  
pp. E953-E955 ◽  
Author(s):  
Elias Dagnew ◽  
Lauren A. Langford ◽  
Frederick F. Lang ◽  
Franco DeMonte
Keyword(s):  
Subcommissural Organ ◽  
Obstructive Hydrocephalus ◽  
Unknown Origin ◽  
Original Description ◽  
Distant Recurrence ◽  
Pineal Region ◽  
Ependymal Cells ◽  
Long Term Follow Up

Abstract OBJECTIVE The pineal region is a rare intracranial site for metastasis. We report three patients initially considered to have metastatic papillary adenocarcinoma to the pineal region. On review, these papillary, keratin-positive neoplasms meet the criteria for papillary tumor of the pineal region (PTPR). CLINICAL PRESENTATION These neoplasms occurred in three women (age range, 37–55 yr). Imaging studies demonstrated well-circumscribed lesions in the pineal region. All patients presented with obstructive hydrocephalus and symptoms attributable to hydrocephalus and tectal compression. INTERVENTION All three patients underwent near total microsurgical resection of the pineal region neoplasm, followed by adjuvant radiotherapy. The two patients with long-term follow-up (56–60 mo) have remained clinically stable without evidence of local or distant recurrence. The first two patients were initially diagnosed as having papillary metastatic carcinoma of unknown origin. The third patient was treated after the recent description of PTPR and met the histopathological diagnostic criteria. Retrospective pathological review of the previous two patients resulted in designation as PTPR. CONCLUSION The morphological features of the tumors in our series, along with the clinical presentations, are similar to those in the original description of the PTPR. Our findings agree with the original hypothesis that the cells composing the PTPR are similar to ependymal cells of the subcommissural organ, thus furthering the hypothesis that the PTPR derives from a specialized ependymocyte associated with the subcommissural organ. The two patients with long-term follow-up (56–60 mo) have remained clinically stable without evidence of local or distant recurrence.

Adult-onset recurrent Kawasaki disease: an unusual cause of fever of unknown origin

2021 ◽  
Vol 14 (8) ◽  
pp. e243704
Author(s):  
Timothy Peter Wynne Jones ◽  
Colin Petrie ◽  
Catriona Sykes
Keyword(s):  
Kawasaki Disease ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Clinical Findings ◽  
Adult Onset ◽  
Rare Presentation ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Long Term Follow Up

We present the case of a 20-year-old man with a background of transposition of the great arteries presenting with fever of unknown origin, who developed a shock like syndrome with respiratory failure necessitating intubation. After extensive investigation, a diagnosis of adult-onset Kawasaki disease was made, and he was successfully treated with IVIg and corticosteroids. We present the clinical findings clinicians should be aware of, and review the literature on managing this rare presentation in adult, highlighting the importance of early diagnosis in improving outcomes. Both children and adults with Kawasaki disease require long-term follow-up, as they remain at increased risk of both coronary artery aneurysms and early acute coronary syndrome.

Syncope of unknown origin: Clinical, noninvasive, and electrophysiologic determinants of arrhythmia induction and symptom recurrence during long-term follow-up

1991 ◽  
Vol 121 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Foad Moazez ◽  
Thomas Peter ◽  
Jay Simonson ◽  
William J. Mandel ◽  
Carol Vaughn ◽  
...  
Keyword(s):  
Unknown Origin ◽  
Long Term Follow Up ◽  
Symptom Recurrence

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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