Sex Differences in Perceived Risks, Distrust, and Willingness to Participate in Clinical Trials

2007 ◽  
Vol 167 (9) ◽  
pp. 905 ◽  
Author(s):  
Eric L. Ding
2003 ◽  
Vol 48 (7) ◽  
pp. 480-484 ◽  
Author(s):  
Daniele Zullino ◽  
Philippe Conus ◽  
François Borgeat ◽  
Charles Bonsack

Background: The feasibility of clinical trials depends, among other factors, on the number of eligible patients, the recruitment process, and the readiness of patients to participate in research. Seeking patients' views about their experience in research projects may allow investigators to develop more effective recruitment and retention strategies. Methods: A total of 100 patients consecutively admitted to a psychiatric university hospital were interviewed with respect to their willingness to participate in a study. For a different study scenario, patients were asked whether they would be ready to participate if such a study were organized in the service and to indicate their reasons for refusing or for participating. Results: The general readiness to participate in a study ranged between 70% and 96%. The prospect of remuneration did not notably augment the potential consent rate. The most common and spontaneous motivation for agreeing to take part in a study was to help science progress and to allow future patients to benefit from improved diagnosis and treatment (87%). The presence or lack of a financial incentive was rarely chosen as an argument to agree (23%) or to refuse (7%) to participate. Patients relied mainly on their treating physicians when contemplating possible participation in a study (family physician [65%] and hospital physician [54%]). Conclusions: Clinicians and, in particular, treating doctors can play an important role in facilitating the recruitment process.


2015 ◽  
Vol 45 ◽  
pp. 443-448 ◽  
Author(s):  
Celia P. Kaplan ◽  
Anna Maria Nápoles ◽  
Steven Narine ◽  
Steven Gregorich ◽  
Jennifer Livaudais-Toman ◽  
...  

Author(s):  
Divyanshu Raheja ◽  
Evelyn Davila ◽  
Eric Johnson ◽  
Rijalda Deović ◽  
Michele Paine ◽  
...  

The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042–5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly.


Vaccine ◽  
2010 ◽  
Vol 28 (29) ◽  
pp. 4638-4643 ◽  
Author(s):  
Qingchun Li ◽  
Fengji Luo ◽  
Zhenhai Zhou ◽  
Shuming Li ◽  
Yingjie Liu ◽  
...  

2020 ◽  
Vol 158 (6) ◽  
pp. S-1225
Author(s):  
Kate T. Avery ◽  
Amy Ratner ◽  
Claire Baker ◽  
Melissa Secord ◽  
Marie Robert ◽  
...  

2016 ◽  
Vol 142 (3) ◽  
pp. 520-524 ◽  
Author(s):  
Elena Igwe ◽  
Julie Woodburn ◽  
Jacyln Davolos ◽  
Cori Shollenberger ◽  
Suzanne M. Miller ◽  
...  

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