Variability of Visual Field Measurements in Normal Subjects and Patients With Retinitis Pigmentosa

Purpose. To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A).Material and Method. Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients. Correlations among total and temporal ONH vessel density and structural and VF parameters were analyzed.Results. In the glaucoma group, total and temporal ONH vessel density were reduced by 24.7% (0.412 versus 0.547;p<0.0001) and 22.88% (0.364 versus 0.472;p=0.001), respectively, as compared with the control group. Univariate analysis showed significant correlation between rim area (mm2) and temporal ONH vessel density (r=0.623;p<0.0001) and total ONH vessel density (r=0.609;p<0.0001). Significant correlations were found between temporal and total ONH vessel density and RNFL, GCC, VF mean deviation, and visual field index.Conclusion. In glaucoma patients OCT-A might detect reduced ONH blood vessel density that is associated with structural and functional glaucomatous damage. OCT-A might become a useful tool for the evaluation of ONH microcirculation changes in glaucoma.

Download Full-text

A novel mutation in the PRPH2 gene in a Chinese pedigree with retinitis pigmentosa and angle-closure glaucoma

BMC Ophthalmology ◽

10.1186/s12886-021-02064-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wei-ning Li ◽

Xiu-juan Du ◽

Yu-ting Zhang ◽

Le-yi Wang ◽

Jing Zhu

Keyword(s):

Visual Field ◽

Retinitis Pigmentosa ◽

Novel Mutation ◽

Genetic Mutation ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

The Novel ◽

Progressive Loss ◽

Whole Exome ◽

Transversion Mutation

Abstract Background Retinitis pigmentosa (RP) is a rare, progressive, and hereditary disorder that leads to the progressive loss of vision and visual field, and in some cases blindness. The specific relationship between RP and glaucoma has been debated for decades. Methods In this study, we examined a Han RP family with concomitant angle-closure glaucoma (ACG), performed an inductive analysis of their clinical features and assistant results, and applied whole-exome sequencing (WES) technology for a molecular diagnosis. Results A novel transversion mutation (c.626 T > A) was identified in the peripherin-2 (PRPH2) gene in the proband, resulting in the substitution of Valine to aspartic acid in codon 209. A full ophthalmic examination showed that the proband with the c.626 T > A mutation had a typical RP manifestation, with close angles; however, the proband’s elder brother, who lacked the novel mutation, had a normal fundus and open angles. Conclusion Our results extend the genetic mutation spectrum of PRPH2 in RP, and provide evidence to support a genetic correlation between RP and ACG.

Download Full-text

flashed in one visual field (here the picture of the violin is flashed in the left visual field), it is conveyed to the contralateral hemisphere (here the right hemisphere). In normal subjects, because of visual transfer across the corpus callosum, both hemispheres see the picture; in split-brain patients, no such transfer is possible, so only one hemisphere sees the picture. A tachistoscope is used to flash the picture for 150msec, faster than the eye can move, otherwise the picture might reach both hemispheres because of eye movements. A fast Fourier transform of the first 400msec of the violin sound is shown at the top of the figure [y axis=time in msec, x=kilohertz (kHz, or 1000cps), and height=relative amplitude (quantized sample value units)]. An example of one of the five melodic structures used to present the instrument sounds (here chromatic-variable) is also shown. In the next trial, a trumpet will play and a picture of a piano is flashed to the left hemisphere, and so on. (See text for further details of the experimental procedure).

Music and the Cognitive Sciences 1990 ◽

10.4324/9780203393284-44 ◽

2004 ◽

pp. 134-135

Keyword(s):

Fourier Transform ◽

Eye Movements ◽

Visual Field ◽

Corpus Callosum ◽

Fast Fourier Transform ◽

Left Visual Field ◽

Right Hemisphere ◽

Normal Subjects ◽

Experimental Procedure ◽

The Right

Download Full-text

A Prediction Method of Visual Field Sensitivity Using Fundus Autofluorescence Images in Patients With Retinitis Pigmentosa

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.61.10.51 ◽

2020 ◽

Vol 61 (10) ◽

pp. 51

Author(s):

Tatsuya Inoue ◽

Kosuke Nakajima ◽

Yohei Hashimoto ◽

Shotaro Asano ◽

Kohdai Kitamoto ◽

...

Keyword(s):

Visual Field ◽

Retinitis Pigmentosa ◽

Fundus Autofluorescence ◽

Prediction Method ◽

Field Sensitivity

Download Full-text

Effect of Short-Term Oral Valproic Acid on Vision and Visual Field in Retinitis Pigmentosa

Ophthalmology and Therapy ◽

10.1007/s40123-012-0006-8 ◽

2012 ◽

Vol 1 (1) ◽

Cited By ~ 5

Author(s):

P. Mahesh Shanmugam ◽

C. K. Minija ◽

Rajesh Ramanjulu ◽

Pradeep Tekwani ◽

Manish Saxena

Keyword(s):

Valproic Acid ◽

Visual Field ◽

Retinitis Pigmentosa ◽

Short Term

Download Full-text

Effect of visual stimulus using central and peripheral visual field on postural control of normal subjects

Journal of Physical Therapy Science ◽

10.1589/jpts.28.1769 ◽

2016 ◽

Vol 28 (6) ◽

pp. 1769-1771 ◽

Cited By ~ 4

Author(s):

Du-Jin Park

Keyword(s):

Visual Field ◽

Postural Control ◽

Visual Stimulus ◽

Normal Subjects ◽

Peripheral Visual Field

Download Full-text

Reading with Visual Field Defects

Perception ◽

10.1068/v970025 ◽

1997 ◽

Vol 26 (1_suppl) ◽

pp. 11-11 ◽

Cited By ~ 1

Author(s):

S Trauzettel-Klosinski

Keyword(s):

Eye Movements ◽

Visual Field ◽

Reading Ability ◽

Reading Speed ◽

Visual Fields ◽

Zero Point ◽

Normal Subjects ◽

Visual Field Defects ◽

Video Tape ◽

Field Defects

The influence of different visual field defects on the reading performance was examined with potential adaptive strategies to improve the reading process in mind. By means of an SLO, the retinal fixation locus (RFL) was determined with the use of single targets and text, and eye movements scanning the text were recorded on video tape. Additionally, eye movements were monitored by an Infrared Limbus Tracker. Visual fields were assessed by the Tübingen Manual and/or automatic perimetry. Normal subjects, and patients with central scotomata, ring scotomata, and hemianopic field defects (HFD) were examined. The main pathological reading parameters were an increase of saccade frequency and regressions per line, and a decrease of reading speed. In patients with field defects involving the visual field centre, fixation behaviour is significant for regaining reading ability. In absolute central scotoma, the lost foveal function promotes eccentric fixation. The remaining problem is insufficient resolution of the RFL, which can be compensated for by magnification of the text. In patients with insufficient size of their reading visual field, due to HFD and ring scotoma, it is crucial that they learn to use a new RFL despite intact foveolar function. Preconditions for reading have been found to be: (1) sufficient resolution of the RFL, (2) a reading visual field of a minimum extent, and (3) intact basic oculomotor function. In patients with visual field defects involving the centre, a sensory-motor adaptation process is required: the use of a new RFL as the new centre of the visual field and as the new zero point for eye-movement coordinates.

Download Full-text