Corneal Perforation in Patients With Vitamin A Deficiency in the United States

1990 ◽  
Vol 108 (3) ◽  
pp. 350 ◽  
Author(s):  
Eric P. Suan
1998 ◽  
Vol 7 (2) ◽  
pp. 89-90
Author(s):  
B L Greenberg ◽  
R D Semba ◽  
P E Vink ◽  
J J Farley ◽  
M Sivapalasingam ◽  
...  

2020 ◽  
Author(s):  
Masako Suzuki ◽  
Tao Wang ◽  
Diana J Garretto ◽  
Carmen R. Isasi ◽  
Wellington V Cardoso ◽  
...  

Abstract Vitamin A is an essential micronutrient that plays critical roles in many biological functions of the body. Limited access to vitamin A-rich food or supplements severely affects tissue and blood levels of vitamin A. Therefore, low serum vitamin A and poverty levels are strongly associated in vitamin A deficiency (VAD) studies that have focused mainly on developing countries. The current national prevalence rate of vitamin A deficiency in the United States is reported to be very low (<1%). However, several studies, including ours, have suggested that people from certain ethnic groups still face a higher proportion of vitamin A deficiency. We hypothesize that the genetic variations between ethnic groups may associate to the VAD proportional differences between women of different ancestries. To assess the associations, we re-analyzed two independent datasets of serum retinol levels of pregnant women in the United States and three datasets of genotypic information of different ancestries. We found that pregnant women with non-Hispanic Black and with Latin American/Afro-Caribbean ancestry have strikingly high proportions of VAD compared to non-Hispanic White and Latin American/Mexican ancestry. Genotypic analyses showed that the minor allele frequencis of genetic variants that associate to serum retinol levels have significantly higher variations between these different ancestries. Our study revealed that VAD rates in the pregnant women differ between different ancestries and that ancestry-dependent genetic variations might contribute to the differences.


2020 ◽  
Author(s):  
Masako Suzuki ◽  
Tao Wang ◽  
Diana J Garretto ◽  
Carmen R. Isasi ◽  
Wellington V Cardoso ◽  
...  

Abstract Vitamin A is an essential micronutrient that plays critical roles in many biological functions of the body. Limited access to vitamin A-rich food or supplements severely affects tissue and blood levels of vitamin A. Therefore, low serum vitamin A and poverty levels are strongly associated in vitamin A deficiency (VAD) studies that have focused mainly on developing countries. The current national prevalence rate of vitamin A deficiency in the United States is reported to be very low (< 1%). However, several studies, including ours, have suggested that people from certain ethnic groups still face a higher proportion of vitamin A deficiency. Here, we re-analyzed two different datasets of serum retinol levels of pregnant females to assess the VAD status differences between women of different ancestries. We found that pregnant females with non-Hispanic Black and with Latin American/Afro-Caribbean ancestry have strikingly high proportions of vitamin A deficiency. Moreover, we identified candidate genetic variants that associate with the disproportions between these different ancestries. Maternal vitamin A deficiency increases the risk of adverse health outcomes for both the mother and offspring later in life. Measuring serum retinol levels of pregnant women in the higher risk groups and provision of food interventions based on genetic information to improve the vitamin A status of at-risk women are needed. Our study strongly suggests that emergency actions need to be taken to reduce vitamin A deficiency in specific, at-risk ethnic groups.


AIDS ◽  
1997 ◽  
Vol 11 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Barbara L. Greenberg ◽  
Richard D. Semba ◽  
Peter E. Vink ◽  
John J. Farley ◽  
Malathy Sivapalasingam ◽  
...  

2020 ◽  
Vol 52 (01) ◽  
pp. 25-28

Kim J, Park MK, Li WQ et al. Association of vitamin A intake with cutaneous squamous cell carcinoma risk in the United States. JAMA Dermatol 2019; doi:10.1001/jamadermatol. 2019.1937


Author(s):  
Taylor K. Ruth ◽  
Joy N. Rumble

Vitamin A deficiency (VAD) is a major issue in developing countries and affects approximately 250 million children, and blinding 500,000 a year. A proposed intervention to VAD is Golden Rice, a rice that has been genetically modified (GM) to contain beta-carotene, the precursor to Vitamin A. However, Golden Rice is often associated with negatively perceived GM food. Because the media is the most trusted source in providing food-risk related information, a framing analysis of Golden Rice in United States and Philippine newspapers was conducted to determine past and current frames used to describe the rice. Understanding such frames could help domestic and international extension workers develop effective communication strategies and educational opportunities. In the United States, GM food was typically the main topic, and Golden Rice was used as a supporting argument. Science and humanitarian frames were used to describe the rice in the U.S. articles. Golden Rice was more often the main topic in the Philippine articles, and more frames were identified: human health, science, policy, risk, and conflict. Golden Rice appears to be in the emergence phase of the framing cycle in the U.S. and in the conflict/resolution phase in the Philippines. Extension in the U.S. and the Philippines should provide education toolkits to journalists about Golden Rice and consider providing press releases to shape the frames used by the media. Extension workers in the Philippines should educate consumers and farmers about the science of Golden Rice to help them create informed opinions toward the product.


2006 ◽  
Vol 134 (Suppl. 2) ◽  
pp. 139-144
Author(s):  
Konstansa Lazarevic ◽  
Maja Nikolic ◽  
Vladimir Mitrovic

Fortification is defined as adding of one or more essential elements to food article, regardless of whether it has been already added to food or not, in order to prevent or correct deficiency of one or more nutrients in the general population or specific population group. Food fortification with minerals and vitamins helps eliminate diseases such as goiter, rickets, beriberi, and pellagra. Significant results have been also achieved in prevention of anemia and vitamin A deficiency. The aforementioned deficiencies can be prevented and eliminated by means of appropriate and diverse nutrition and supplementation of deficient micronutrients, but on the national level, food fortification is the best solution. Two basic conditions for the application of fortification are the following: that the food article is in wide use and that it is cheap (available). The purpose of our paper was to show the results achieved by means of fortification in various countries in order to build up the basis for similar propositions in our country (Serbia and Montenegro). Owing to fortification in Asia, the number of cretinism cases has been reduced by half while sugar fortification significantly reduced the number of children with vitamin A deficiency. For more than 50 years, flour fortification with iron in order to prevent its deficiency and anemia, has been successfully applied in the United States and Canada, and as of recently in some countries of Africa and South America. The analysis of the results leads to the conclusion that food fortification has had beneficial health effects in the communities where it has been applied.


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