Verrucous Carcinoma of the Larynx: Possible Human Papillomavirus Etiology

1985 ◽  
Vol 111 (11) ◽  
pp. 709-715 ◽  
Author(s):  
A. L. Abramson ◽  
J. Brandsma ◽  
B. Steinberg ◽  
B. Winkler
1993 ◽  
Vol 103 (4) ◽  
pp. 416-420 ◽  
Author(s):  
Jan L. Kasperbauer ◽  
Gerard L. O'Halloran ◽  
Mark J. Espy ◽  
Thomas F. Smith ◽  
Jean E. Lewis

1996 ◽  
Vol 110 (8) ◽  
pp. 742-747 ◽  
Author(s):  
Manuel López-Amado ◽  
Tomás García-Caballero ◽  
Ascensión Lozano-Ramírez ◽  
Torcuato Labella-Caballero

AbstractThe incidence of p53 antigen and human papillomavirus (HPV) expression in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using immunohistochemistry.The p53 oncoprotein was detected in four of 10 tissue samples (40 per cent). The same number of tumours had HPV antigen, and three cases had both p53 oncoprotein and HPV antigen. All positive cases were from heavy smokers and drinkers.After surgical treatment, no tumour recurrence was present in our series. Four patients developed a second head and neck neoplasm and death occurred in three. Three of the patients with second tumour had p53 positive immunoreactivity and two had p13 and HPV expression.Verrucous carcinoma of the larynx presented with overexpression of p53 antigen in a similar percentage to other head and neck cancers. The p53 immunohistochemical determination is well correlated with HPV detection and could have prognostic value in these tumours, but no statistical evidence was present.


2020 ◽  
pp. 095646242096194
Author(s):  
Marialuisa Corbeddu ◽  
Luca Pilloni ◽  
Roberta Satta ◽  
Laura Atzori ◽  
Franco Rongioletti

We report two cases of histologically documented pseudoepitheliomatous keratotic and micaceous balanitis in middle-aged male patients, which showed positivity for low-risk serotype human papillomavirus DNA. To our knowledge, only one other case has been documented. Further immunohistochemical proliferative markers were performed and compared to literature findings in penile epithelial proliferations. Evolution to invasive verrucous carcinoma has been associated with absence of HPV DNA. Thus, if confirmed by further studies, HPV testing should be included in pseudoepitheliomatous keratotic and micaceous balanitis assessment to address prognosis, and management.


2011 ◽  
Vol 165 (3) ◽  
pp. 694-696 ◽  
Author(s):  
J-J. Park ◽  
S-H. Kim ◽  
J.H. Lee ◽  
J-B. Lee ◽  
S.J. Yun

Tumor Biology ◽  
2010 ◽  
Vol 32 (2) ◽  
pp. 409-416 ◽  
Author(s):  
José Vieira de Spíndula-Filho ◽  
Aparecido Divino da Cruz ◽  
Angélica Ferreira Oton-Leite ◽  
Aline Carvalho Batista ◽  
Cláudio Rodrigues Leles ◽  
...  

1993 ◽  
Vol 103 (3) ◽  
pp. 253???257 ◽  
Author(s):  
Patrick Hagen ◽  
George D. Lyons ◽  
Christian Haindel

2019 ◽  
Vol 129 (9) ◽  
pp. 1964-1965 ◽  
Author(s):  
Brent A. Chang ◽  
Sanford Katz ◽  
Anvesh R. Kompelli ◽  
Cherie‐Ann O. Nathan

2020 ◽  
Vol 10 ◽  
Author(s):  
Thejus T. Jayakrishnan ◽  
Stephen Abel ◽  
Erik Interval ◽  
Athanasios Colonias ◽  
Rodney E. Wegner

1991 ◽  
Vol 16 (2) ◽  
pp. 160-162 ◽  
Author(s):  
C.A. MILFORD ◽  
P.E. O'FLYNN

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