Aim. To study radiological features of pulmonary tuberculosis according to the polymorphism of the gene HLA-DRB1. Materials and methods. Radiologically examined 73 newly diagnosed patients with different clinical forms of pulmonary tuberculosis and genotyped for HLA-DRB1 by PCR-MSSR. Results. The analysis of associations specificities gene HLA-DRB1* depending on the x-ray picture of the disease. It is found that the specificity (*04, *11, *13, *14 and *16 gene HLA- DRB1 *) positively associated with the amount of a specific process for more than three segments and destruction of lung tissue. Genotypes with 01*, 07*, 08*, 10*, 12*, 15* and 16* specificities HLA- DRB1* lesion volume were less than three segments, with a predominance of productive inflammation of the lung tissue. Conclusions. X-ray picture of the 60.3% of patients with newly diagnosed pulmonary tuberculosis characterized by common (equity, polysegmental) lesions of the lung tissue. The obtained results of the study of gene polymorphism immune response HLA- DRB1*, show some specificity, in particular *04, *11, *13 and *16 alleles of HLA-DRB1*, possibly responsible for massive infiltration and destruction of lung tissue.
Radiological features of pulmonary tuberculosis depending on
the gene polymorphism of HLA-DRB1.