Methisazone for prophylaxis against chickenpox; a small clinical trial

ABSTRACTThere is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax.

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The small clinical trial: is there a better way?

Thorax ◽

10.1136/thx.41.11.822 ◽

1986 ◽

Vol 41 (11) ◽

pp. 822-823 ◽

Cited By ~ 3

Author(s):

R J Prescott

Keyword(s):

Clinical Trial ◽

Small Clinical Trial

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Data entry training for a small clinical trial

Controlled Clinical Trials ◽

10.1016/0197-2456(91)90302-3 ◽

1991 ◽

Vol 12 (5) ◽

pp. 706

Author(s):

Scott D. Corley ◽

Grace Ng ◽

Mary Jo Gillespie

Keyword(s):

Clinical Trial ◽

Data Entry ◽

Small Clinical Trial

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MURMURS AND NOISE CAUSED BY ARTERIAL NARROWING – THEORY AND CLINICAL PRACTICE

Fluctuation and Noise Letters ◽

10.1142/s0219477506003574 ◽

2006 ◽

Vol 06 (04) ◽

pp. L415-L425 ◽

Cited By ~ 1

Author(s):

MARTIN BIER ◽

ORVILLE W. DAY ◽

DAVID W. PRAVICA

Keyword(s):

Clinical Trial ◽

Duplex Ultrasound ◽

Type Equation ◽

Decay Rates ◽

Navier Stokes ◽

Navier Stokes Equation ◽

Small Clinical Trial ◽

Complex Eigenvalues ◽

Flow Through ◽

Sound Spectrum

Arterial narrowing can cause an audible whirling in the blood flow. We propose diagnosing such narrowing by simply recording that sound and analyzing its spectrum. We show how the Navier-Stokes equation for flow through a narrowing can be turned into a Schrödinger type equation. The complex eigenvalues of the latter equation give the frequencies and decay rates of the vortices present in the whirling pattern. Our diagnosis is based on understanding the relation between features in the sound spectrum and the severity of the narrowing. Today the most commonly used method of diagnosis is duplex ultrasound. In a small clinical trial our method appears to be as good as duplex ultrasound.

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Double-blind evaluation of chemonucleolysis for herniated lumbar discs

Journal of Neurosurgery ◽

10.3171/jns.1978.49.6.0816 ◽

1978 ◽

Vol 49 (6) ◽

pp. 816-827 ◽

Cited By ~ 40

Author(s):

Albert N. Martins ◽

Archimedes Ramirez ◽

James Johnston ◽

P. Robert Schwetschenau

Keyword(s):

Clinical Trial ◽

Clinical Trials ◽

Conservative Management ◽

Double Blind Study ◽

Double Blind ◽

Content Type ◽

Treatment Groups ◽

Small Clinical Trial ◽

The Difference ◽

Fine Print

✓ Sixty-six patients with symptomatic herniated lumbar discs refractory to the usual conservative management were allocated at random into one of two treatment groups according to a double-blind protocol: 31 received chymopapain intradiscally (chemonucleolysis) and 35 received a placebo intradiscally. Symptoms remained significantly improved 1 year or more after injection for 55% of those treated with chymopapain and for 46% of those treated with placebo. The difference is not statistically significant. However, to discard chemonucleolysis on the basis of this one small clinical trial may be premature. Since continuing controversy has re-established a climate in which another double-blind study of chemonucleolysis is ethically feasible and scientifically desirable, we favor additional clinical trials under a tightly controlled protocol to help resolve the issue.

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Intermittent Roxithromycin for Preventing Progression of Small Abdominal Aortic Aneurysms: Long-Term Results of a Small Clinical Trial

Vascular and Endovascular Surgery ◽

10.1177/1538574409335037 ◽

2009 ◽

Vol 43 (5) ◽

pp. 452-456 ◽

Cited By ~ 19

Author(s):

Annette Høgh ◽

Steen Vammen ◽

Lars Ostergaard ◽

Jette B. Joensen ◽

Esklid W. Henneberg ◽

...

Keyword(s):

Clinical Trial ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Long Term Results ◽

Small Clinical Trial ◽

Abdominal Aortic

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Virtual Reality Treatment Displaying the Missing Leg Improves Phantom Limb Pain: A Small Clinical Trial

Neurorehabilitation and Neural Repair ◽

10.1177/15459683211054164 ◽

2021 ◽

pp. 154596832110541

Author(s):

Elisabetta Ambron ◽

Laurel J. Buxbaum ◽

Alexander Miller ◽

Harrison Stoll ◽

Katherine J. Kuchenbecker ◽

...

Keyword(s):

Clinical Trial ◽

Virtual Reality ◽

Lower Limb ◽

Phantom Limb Pain ◽

Lower Limb Amputation ◽

Phantom Limb ◽

Limb Amputation ◽

Limb Pain ◽

Small Clinical Trial ◽

Leg Movements

Background Phantom limb pain (PLP) is a common and in some cases debilitating consequence of upper- or lower-limb amputation for which current treatments are inadequate. Objective This small clinical trial tested whether game-like interactions with immersive VR activities can reduce PLP in subjects with transtibial lower-limb amputation. Methods Seven participants attended 5–7 sessions in which they engaged in a visually immersive virtual reality experience that did not require leg movements (Cool! TM), followed by 10–12 sessions of targeted lower-limb VR treatment consisting of custom games requiring leg movement. In the latter condition, they controlled an avatar with 2 intact legs viewed in a head-mounted display (HTC Vive TM). A motion-tracking system mounted on the intact and residual limbs controlled the movements of both virtual extremities independently. Results All participants except one experienced a reduction of pain immediately after VR sessions, and their pre session pain levels also decreased over the course of the study. At a group level, PLP decreased by 28% after the treatment that did not include leg movements and 39.6% after the games requiring leg motions. Both treatments were successful in reducing PLP. Conclusions This VR intervention appears to be an efficacious treatment for PLP in subjects with lower-limb amputation.

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