Excess Mortality Among Psychiatric Patients

Of 5,412 patients admitted to the University of Iowa Psychiatric Hospital over a ten-year period, forty-six died of cancer during follow-up, which did not differ significantly from expected. Significant excess mortality from cancer was present within the first two years of follow-up. At risk during this period were women and patients with organic mental disorders. A review of relevant literature is presented.

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Death rate from ischaemic heart disease in Western Australian psychiatric patients 1980–1998

The British Journal of Psychiatry ◽

10.1192/bjp.182.1.31 ◽

2003 ◽

Vol 182 (1) ◽

pp. 31-36 ◽

Cited By ~ 187

Author(s):

David M. Lawrence ◽

Cashel D'Arcy ◽

J. Holman ◽

Assen V. Jablensky ◽

Michael S. T. Hobbs

Keyword(s):

Mental Illness ◽

Heart Disease ◽

General Population ◽

Hospital Admission ◽

Ischaemic Heart Disease ◽

Excess Mortality ◽

Hospital Admissions ◽

Psychiatric Patients ◽

Admission Rates ◽

People With Mental Illness

BackgroundPeople with mental illness suffer excess mortality due to physical illnesses.AimsTo investigate the association between mental illness and ischaemic heart disease (IHD) hospital admissions, revascularisation procedures and deaths.MethodA population-based record-linkage study of 210 129 users of mental health services in Western Australia during 1980–1998. IHD mortality rates, hospital admission rates and rates of revascularisation procedures were compared with those of the general population.ResultsIHD (not suicide) was the major cause of excess mortality in psychiatric patients. In contrast to the rate in the general population, the IHS mortality rate in psychiatric patients did not diminish over time. There was little difference in hospital admission rates for IHD between psychiatric patients and the general community, but much lower rates of revascularisation procedures with psychiatric patients, particularly in people with psychoses.ConclusionsPeople with mental illness do not receive an equitable level of intervention for IHD. More attention to their general medical care is needed.

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Excess mortality among psychiatric patients. The Iowa Record-Linkage Study

JAMA ◽

10.1001/jama.253.1.58 ◽

1985 ◽

Vol 253 (1) ◽

pp. 58-61 ◽

Cited By ~ 24

Author(s):

D. W. Black

Keyword(s):

Record Linkage ◽

Excess Mortality ◽

Psychiatric Patients ◽

Linkage Study

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Excess Mortality Among Formerly Hospitalized Child Psychiatric Patients

Archives of General Psychiatry ◽

10.1001/archpsyc.1988.01800270095011 ◽

1988 ◽

Vol 45 (3) ◽

pp. 277 ◽

Cited By ~ 22

Author(s):

Samuel Kuperman

Keyword(s):

Excess Mortality ◽

Psychiatric Patients ◽

Child Psychiatric

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Obstructive asphyxia: a cause of excess mortality in psychiatric patients

Irish Journal of Psychological Medicine ◽

10.1017/s079096670000776x ◽

2003 ◽

Vol 20 (3) ◽

pp. 88-90 ◽

Cited By ~ 14

Author(s):

Eleanor Corcoran ◽

Dermot Walsh

Keyword(s):

Patient Population ◽

Excess Mortality ◽

Psychiatric Patients ◽

Factors Associated

AbstractThe purpose of this study was to determine the number of deaths which were caused by choking in a 10 year period in the Irish psychiatric in-patient population and the factors associated with such deaths.

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Excess mortality among psychiatric patients

JAMA ◽

10.1001/jama.254.3.360b ◽

1985 ◽

Vol 254 (3) ◽

pp. 360b-360

Author(s):

E. Masterson

Keyword(s):

Excess Mortality ◽

Psychiatric Patients

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Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia

Consortium Psychiatricum ◽

10.17816/cp101 ◽

2021 ◽

Vol 2 (3) ◽

pp. 35-43

Author(s):

Anna I. Tkachev ◽

Elena A. Stekolshchikova ◽

Anna Yu. Morozova ◽

Nikolay A. Anikanov ◽

Yana A. Zorkina ◽

...

Keyword(s):

Cardiovascular Disease ◽

Blood Plasma ◽

Excess Mortality ◽

Psychiatric Patients ◽

Psychotic Episode ◽

Genetic Studies ◽

First Psychotic Episode ◽

Somatic Comorbidities ◽

Lipid Compounds ◽

Independent Cohort

INTRODUCTION: Schizophrenia, although a debilitating mental illness, greatly affects individuals physical health as well. One of the leading somatic comorbidities associated with schizophrenia is cardiovascular disease, which has been estimated to be one of the leading causes of excess mortality in patients diagnosed with schizophrenia. Although the shared susceptibility to schizophrenia and cardiovascular disease is well established, the mechanisms linking these two disorders are not well understood. Genetic studies have hinted toward shared lipid metabolism abnormalities co-occurring in the two disorders, while lipid compounds have emerged as prognostic markers for cardiovascular disease. In particular, three ceramide species in the blood plasma, Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1), have been robustly linked to the latter disorder. AIM: We aimed to assess the differences in abundances of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) in the blood plasma of schizophrenia patients compared to healthy controls. METHODS: We measured the abundances of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) in a cohort of 82 patients with schizophrenia and 138 controls without a psychiatric diagnosis and validated the results using an independent cohort of 26 patients with schizophrenia, 55 control individuals, and 19 patients experiencing a first psychotic episode. RESULTS: We found significant alterations for all three ceramide species Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) and a particularly strong difference in concentrations between psychiatric patients and controls for the ceramide species Cer(d18:1/18:0). CONCLUSIONS: The alteration of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) levels in the blood plasma might be a manifestation of metabolic abnormalities common to both schizophrenia and cardiovascular disease.

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