scholarly journals Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion

JAMA ◽  
2015 ◽  
Vol 314 (24) ◽  
pp. 2641 ◽  
Author(s):  
Najib M. Rahman ◽  
Justin Pepperell ◽  
Sunita Rehal ◽  
Tarek Saba ◽  
Augustine Tang ◽  
...  
1998 ◽  
Vol 92 (4) ◽  
pp. 633-637 ◽  
Author(s):  
H. Ishikawa ◽  
H. Satoh ◽  
Y.T. Yamashita ◽  
H. Kamma ◽  
T. Naito ◽  
...  

JAMA ◽  
2012 ◽  
Vol 307 (22) ◽  
pp. 2383 ◽  
Author(s):  
Helen E. Davies ◽  
Eleanor K. Mishra ◽  
Brennan C. Kahan ◽  
John M. Wrightson ◽  
Andrew E. Stanton ◽  
...  

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19608-e19608
Author(s):  
Apirudee Porntepkasemson ◽  
Sarayut Lucien Geater

e19608 Background: Malignant pleural effusion is one of the most common presenting symptoms in lung cancer. There has been no large RCT comparing large-bore and small-bore chest tubes in terms of pain and efficacy of management. Methods: A randomized controlled trial was conducted in 2011. Patients with malignant pleural effusion were randomly allocated to receive either a large-bore or small-bore chest tube. The primary objective was to compare pain using the Numeric Rating Scale. Other objectives included the efficacy of the drainage and pleurodesis and any complications were recorded. Results: Each arm comprised 21 patients. Median age was 61.2 years. Thirty-eight patients (90.5%) had adenocarcinoma; 14(33.3%) had received systemic chemotherapy. Pain score did not differ significantly between the groups from the time of tube insertion to removal. However, pain rose from day 4 until day 9 in the small-bore group. The proportion of patients requiring a second chest tube was higher in the small-bore group (small-bore = 7, 33.3 %; large-bore = 1, 4.8%; p 0.052). Complications were higher in the small-bore group. Five patients were complicated by tube occlusion which occurred only in the small-bore group (23.8 %, p 0.048). Times from tube insertion to lung expansion, to pleurodesis and to chest tube removal did not differ significantly between groups. Pleurodesis was effective in 70-80 % in both groups at the 28-day follow-up. Conclusions: No differences between large-bore and small-bore chest tubes were seen in pain, efficacy of drainage or success of pleurodesis. However, small-bore chest tubes had a higher rate of occlusion and more frequently required additional tube insertion.


2019 ◽  
Vol 5 (2) ◽  
pp. e20-e20
Author(s):  
Masoud Rahimian ◽  
Salar Khazani Fard ◽  
Mohammad Samet ◽  
Fatemeh Aghaei Meybodi

Introduction: About 50% of patients with metastatic cancers suffer from malignant pleural effusion. The goals of treatment for these patients should be to relieve pain, restore normal function, reduce or eliminate hospitalization, and make efficient use of medical care resources. Objectives: This study aimed to evaluate the effect of negative pressure suction on the success rate of pleurodesis with bleomycin on malignant pleural effusion. Patients and Methods: This study was conducted as before-after interventional study, without randomization. For all patients, 1 mg/kg bleomycin diluted with 50 mL distilled water, was injected into the chest tube. After changing the position of the patient, the clamp was opened and the tube was connected to the central suction with two chest bottles. The negative pressure suction was 20 cmH2O. Before intervention and four weeks after the intervention, a simple decubitus lateral chest X-ray was taken and the amount of malignant pleural effusion was assessed and compared with the amount of pleural effusion before the insertion of the chest tube. If the pleural effusion level was greater than 10 mm from the outer part of the chest, pleurodesis was considered unsuccessful Results: The mean age of patients was 60.44 ± 10.48 years (32-79 years); of which 12 patients (48%) were male. The most common cancer was lung cancer (48%). The success rate of treatment with bleomycin accompanied by negative pressure suction was 80% without a significant relationship with age, gender and type of cancer. Additionally, the results showed the improvement of the respiratory status and the pain level after the pleurodesis. The only side effect after bleomycin injection was fever in 84% of patients. Conclusion: Bleomycin treatment accompanied by negative pressure suction can improve malignant pleural effusion and this method is recommended for these patients.


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