Total lymphocyte count as a predictor of absolute CD4+ count and CD4+ percentage in HIV-infected persons

Introduction: In resource-limited settings, due to the high cost of CD4 cell count testing, physicians must decide about opportunistic infection (OI) prophylaxis without a laboratory evaluation of HIV stage and level of immune suppression. This study aimed to evaluate the correlation of total lymphocyte count (TLC), an inexpensive laboratory parameter, to CD4 count, and to determine a range of TLC cut-offs for the initiation of OI prophylaxis that is appropriate for resource-limited settings. Methodology: Spearman correlation between CD4 count and TLC was assessed in patients attending the Anti-Retroviral Therapy (ART) centre at Mysore, India. Positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity of various TLC cut-offs were computed for CD4 counts < 200 cells/mm3. Correlation and statistical indices were computed for all patients and for HIV patients with active tuberculosis. Results: Good correlation was noted between the 106 paired TLC and CD4 counts (r = 0.3497).TLC < 1200cells/mm3 had 88.14% sensitivity and 34.78% specificity for CD4 count < 200 cells/mm3. In those patients with active tuberculosis, TLC< 2000cells/mm3 had 95.24% sensitivity and 100% specificity for CD4 count < 200cells/ mm3. Conclusions: TLC could serve as a low-cost tool for determining when to initiate prophylaxis in resource-constrained settings.

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Evaluation of the probability of using total lymphocyte count as an alternative to CD4 count in initiation of art

Bayero Journal of Pure and Applied Sciences ◽

10.4314/bajopas.v6i2.18 ◽

2014 ◽

Vol 6 (2) ◽

pp. 89

Author(s):

J Tijjani ◽

PA Okafor

Keyword(s):

Lymphocyte Count ◽

Total Lymphocyte Count ◽

Cd4 Count ◽

Total Lymphocyte

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Correlation Between Total Lymphocyte Count, Hemoglobin, Hematocrit and CD4 Count in HIV Patients in Nigeria

Pakistan Journal of Biological Sciences ◽

10.3923/pjbs.2014.570.573 ◽

2014 ◽

Vol 17 (4) ◽

pp. 570-573 ◽

Cited By ~ 2

Author(s):

Charles Iheanyichi Emuchay ◽

Shemaiah Olufemi Okeniyi ◽

Joshua Olusegun Okeniyi

Keyword(s):

Lymphocyte Count ◽

Total Lymphocyte Count ◽

Cd4 Count ◽

Hiv Patients ◽

Total Lymphocyte

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Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings

Journal of Biomarkers ◽

10.1155/2017/7907352 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Louis Boafo Kwantwi ◽

Bismark Kwame Tunu ◽

Daniel Boateng ◽

Dan Yedu Quansah

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Sensitivity And Specificity ◽

Lymphocyte Count ◽

Total Lymphocyte Count ◽

Cd4 Count ◽

Traditional Role ◽

Prognostic Information ◽

Cross Sectional ◽

Total Lymphocyte

Background. In view of the lack of evidence on the possibility of an economically viable, easy, and readily available biomarker to substitute the traditional role of CD4 counts in HIV disease progression, this study seeks to investigate the potential use of body mass index (BMI), haemoglobin (Hb), and total lymphocyte count (TLC) as surrogate biomarkers for monitoring the disease. Methods. This cross-sectional study was undertaken at the antiretroviral clinic (ART) of the Bomso Hospital, Kumasi, Ghana. We recruited 384 individuals who were 18 years or older and confirmed HIV seropositive patients. Blood samples were assayed for TLC and Hb. Weight and height were determined and BMI was calculated. Result. At a cut-off point of 12.15 g/dL, Hb had sensitivity and specificity of 73.9% and 56.8%, respectively, whereas BMI had 69.6% and 80.1% sensitivity and specificity, respectively. The sensitivity and specificity were also 100% among the studied participants at a cut-off point of 1200 mm−3 for TLC. There was a significant positive correlation between CD4 count and Hb (rho 0.262, p=0.0001), BMI (rho 0.301, p=0.0001), and TLC (rho 0.834, p=0.0001). Conclusion. The study demonstrates that TLC, Hb, and BMI may provide some useful prognostic information independent of that provided by CD4 count.

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