Total Lymphocyte Count as a Surrogate Marker to Predict CD4 Count in Human Immunodeficiency Virus-infected Children

2012 ◽  
Vol 31 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Yuming Wang ◽  
Yuqian Li ◽  
Chongjian Wang ◽  
Shuying Liang ◽  
Jinling Guo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymphocyte Count ◽  
Surrogate Marker ◽  
Total Lymphocyte Count ◽  
Cd4 Count ◽  
Total Lymphocyte ◽  
Immunodeficiency Virus

scholarly journals Human immunodeficiency virus in institutionalized elderly people

2016 ◽  
Vol 134 (6) ◽  
pp. 528-533
Author(s):  
Milton Luiz Gorzoni ◽  
Sueli Luciano Pires ◽  
Lilian de Fátima Costa Faria ◽  
Márcia Regina Valadares Aguado ◽  
Miriam Carmen Santana
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B ◽  
Lymphocyte Count ◽  
Antiretroviral Drugs ◽  
Total Lymphocyte Count ◽  
Hiv Positive ◽  
Hiv Diagnosis ◽  
Total Lymphocyte ◽  
Hospital Infection Control ◽  
Immunodeficiency Virus

ABSTRACT CONTEXT AND OBJECTIVE: A search in the SciELO and PubMed databases showed few studies on human immunodeficiency virus (HIV) positive individuals in long-term care institutions (LTCIs), thus prompting the present study. The aim of this study was to ascertain whether there were any HIV-positive individuals in LTCIs for the elderly. DESIGN AND SETTING: Cross-sectional study in which the Hospital Infection Control Committee (HICC) of a 405-bed LTCI was consulted. METHODS: The medical records of 405 individuals interned in the LTCI who had been tested for HIV infection were requested for analysis of the following variables: [1] age and gender; [2] length of stay at LTCI (months); [3] causes and diagnoses on admission to LTCI according to International Classification of Diseases, 10th edition; [4] date of HIV diagnosis; [5] seropositivity for syphilis and hepatitis B and C viruses; [6] medications used at last prescription in medical file; and [7] mean CD4 lymphocyte count based on: total lymphocyte count/6 and total lymphocyte count x 0.8 x 0.2 or 0.3. RESULTS: Four men were HIV-positive, with mean age 71.2 ± 8.6 years, LTCI stay 74.2 ± 38.1 months and length of HIV diagnosis 24.5 ± 17 months (confirmed by HICC standard screening). Three had stroke sequelae; one, dementia syndrome; two, seropositivity for syphilis; two, hepatitis B and one, hepatitis C. The main drugs used were lamivudine, zidovudine, lopinavir, ritonavir, levothyroxine, omeprazole, ranitidine, lactulose and risperidone. The estimated CD4 count was 341 ± 237/mm3. CONCLUSIONS: HIV-positive individuals are present in LTCIs, diagnosable through serological screening and treatable with antiretroviral drugs.

scholarly journals Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus

Sari Pediatri ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 81
Author(s):  
Aulia Fitri Swity ◽  
Djatnika Setiabudi ◽  
Herry Garna
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Latar belakang.Epidemi infeksi human immunodeficiency virus (HIV) merupakan tantangan besar dalam permasalahan kesehatan di dunia. Di Indonesia, jumlah kasus HIV/AIDS anak semakin meningkat tiap tahunnya. Pemantauan jumlah CD4 dapat membantu memutuskan dimulainya pemberian terapi anti- CD4 dapat membantu memutuskan dimulainya pemberian terapi antiretroviral/ARV, tetapi pemeriksaannya mahal dan tidak selalu tersedia di sarana kesehatan. Total lymphocyte count (TLC) diajukan sebagai panduan alternatif selain jumlah CD4 pada keadaan sarana kesehatan yang terbatas. Tujuan. Menentukan korelasi TLC dengan jumlah CD4, dan menentukan jumlah CD4 berdasarkan pemeriksaan TLC pada anak HIV.Metode. Penelitian potong lintang berupa observasional analitik, pengambilan data secara retrospektif rekam medis anak HIV yang dirawat inap di Departemen/SMF Ilmu Kesehatan Anak dan rawat jalan di Klinik Teratai Rumah Sakit Dr. Hasan Sadikin, Bandung. Dilakukan analisis regresi linier pada faktor-faktor yang berhubungan bermakna dengan CD4 untuk menentukan korelasi TLC dengan CD4, serta nilai hitung CD4 dari TLC. Kemaknaan ditentukan berdasarkan nilai p<0,05. Hasil.Subjek penelitian 67 anak HIV, terdiri dari 35 (52%) laki-laki dan 32 (48%) perempuan. Rentang jumlah CD4 berkisar antara 6–3.094 mm3, rerata 444,3 mm3(SD 536,3), median 241 mm3,dan rentang jumlah TLC antara 525–10.738, rerata 3.352,4 (SD 2.020,4), median 2.898. Analisis regresi menunjukkan hubungan linier antara jumlah CD4 sebagai variabel tergantung (Y) dan TLC sebagai variabel bebas (X) menggunakan persamaan Y= -158,209+0,180X. Didapatkan korelasi kuat antara TLC dan jumlah CD4 (r=0,68; p<0,001). Kesimpulan.Terdapat hubungan positif antara jumlah limfosit dan jumlah CD4. Jumlah CD4 pada pasien HIV anak dapat diperkirakan dari jumlah limfosit. Diperlukan penelitian lebih lanjut untuk menentukan cut off point TLC dalam inisiasi ARV

scholarly journals Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Nyawira Githinji ◽  
Elizabeth Maleche-Obimbo ◽  
Moses Nderitu ◽  
Dalton C Wamalwa ◽  
Dorothy Mbori-Ngacha
Keyword(s):  
Lymphocyte Count ◽  
Surrogate Marker ◽  
Total Lymphocyte Count ◽  
Cd4 Counts ◽  
Total Lymphocyte ◽  
Hiv 1
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