scholarly journals Diastolic Blood Pressure and the J-Curve—Causal Effect or Confounding?

2021 ◽  
Vol 4 (10) ◽  
pp. e2130031
Author(s):  
Sydney E. Hartsell ◽  
Srinivasan Beddhu
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Causal Effect ◽  
J Curve

Is There a J Curve Distribution for Diastolic Blood Pressure?

1992 ◽  
Vol 14 (1-2) ◽  
pp. 139-149 ◽  
Author(s):  
Christopher G. Isles ◽  
David J. Hole
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
J Curve

Abstract 031: Diastolic Blood Pressure, Coronary Artery Calcium, and Cardiac Outcomes in the Multi-ethnic Study of Atherosclerosis

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
John W McEvoy ◽  
Faisal Rahman ◽  
Mahmoud Al Rifai ◽  
Michael Blaha ◽  
Khurram Nasir ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Confidence Interval ◽  
Diastolic Blood Pressure ◽  
Coronary Artery Calcium ◽  
J Curve ◽  
Increased Risk ◽  
All Cause Mortality

Diastolic blood pressure (BP) has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic BP, our objective was to test whether the J-curve is most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic BP category is associated with coronary heart disease events, stroke, and mortality. Analyses were conducted in the sample overall and after stratification by coronary artery calcium score. In multivariable-adjusted analyses, compared with diastolic BP of 80 to 89 mmHg (reference), persons with diastolic BP <60 mmHg had increased risk of coronary heart disease events (HR 1.69 [95% confidence interval 1.02-2.79]) and all-cause mortality (HR 1.48 [95% confidence interval 1.10-2.00]), but not stroke. After stratification, associations of diastolic BP <60 mmHg with events were present only among participants with coronary artery calcium >0. Diastolic BP <60 mmHg was not associated with events when coronary artery calcium was zero. We also found no interaction in the association between low diastolic BP and events based on race. In conclusion, diastolic blood pressure <60 mmHg was associated with increased risk of coronary heart disease events and all-cause mortality in the sample overall, but this association appeared strongest among individuals with elevated CAC; suggesting that added caution may be needed when pursuing intensive BP treatment targets among persons with subclinical atherosclerosis.

scholarly journals The J-curve between Diastolic Blood Pressure and Risk of All-cause and Cardiovascular Death

2018 ◽  
Vol 48 (1) ◽  
pp. 36 ◽  
Author(s):  
Heejin Kimm ◽  
Yejin Mok ◽  
Sun Ju Lee ◽  
Sunmi Lee ◽  
Joung Hwan Back ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Cardiovascular Death ◽  
J Curve

scholarly journals 430 Relation of blood pressure to coronary artery calcium and mortality

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
I J Cho ◽  
J H Lee ◽  
S Y Choi ◽  
E J Chun ◽  
S H Park ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Diastolic Blood Pressure ◽  
Coronary Artery Calcium ◽  
Multicenter Observational Study ◽  
J Curve ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Study Population ◽  
Artery Disease

Abstract Background Diastolic blood pressure has a J-curve relation with coronary heart disease and death, but it is debating whether a J-curve association exists in general population. We aimed to assess the relation of blood pressure to mortality, and whether their association is interacted with presence of high coronary artery calcium (CAC). Methods The KOICA registry is a retrospective, multicenter observational study designed to investigate the effectiveness and prognostic value of CAC score for primary prevention of cardiovascular disease in asymptomatic Korean adults. The association between CAC score and blood pressure was assessed. Patients were divided into 2 groups according to the baseline CACS (&gt; 300 and ≤ 300), and all-cause mortality was assessed. Results The study population composed 48903 subjects with a mean age of 54 ± 9. There were 425 (0.9%) deaths during follow-up. At baseline, SBP (systolic blood pressure) more than 110 mmHg and DBP (diastolic blood pressure) more than 80 mmHg was associated with increased risk for CACS &gt; 300. In patients with baseline CACS ≤ 300, all-cause mortality was increased in patients with SBP of 110-119 mmHg (HR 1.47, p = 0.023), 130-139 mmHg (HR 1.72, p = 0.002) and ≥ 140 mmHg (HR 1.47, p = 0.042) compared to SBP of 120-129 mmHg, whereas DBP did not predict all-cause mortality. In contrast, SBP was not associated to all-cause mortality in patients with CACS &gt; 300, whereas DBP &lt; 60 mmHg (HR 3.53, p =0.018) and 70-79 mmHg (HR 2.21, p = 0.042) was associated with increased risk for all-cause mortality compared to DBP of 80-89 mmHg. Conclusion Low DBP was associated with increased risk for all-cause mortality in subjects with high CAC score, suggesting high-risk for coronary artery disease. However, this J-curve relation was not shown in the population with low CAC score.

scholarly journals Reverse J-Curve Relation between Diastolic Blood Pressure and Severity of Coronary Artery Lesion in Hypertensive Patients with Angina Pectoris.

2002 ◽  
Vol 25 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Naoyuki HASEBE ◽  
Shinsuke KIDO ◽  
Akira IDO ◽  
Kenjiro KIKUCHI
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Diastolic Blood Pressure ◽  
Coronary Artery Lesion ◽  
Hypertensive Patients ◽  
J Curve

The J-curve relationship of treated diastolic blood pressure to mortality risk: Is it real? Is it clinically meaningful?

2007 ◽  
Vol 1 (3) ◽  
pp. 204-208 ◽  
Author(s):  
William B. Kannel ◽  
Ramachandran S. Vasan
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Mortality Risk ◽  
J Curve ◽  
Relationship Of

scholarly journals The diastolic blood pressure J-curve revisited: An update

2021 ◽  
pp. 100065
Author(s):  
Edward J. Filippone ◽  
Andrew J. Foy ◽  
Gerald V. Naccarelli
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
J Curve

scholarly journals The Diastolic Blood Pressure J-Curve in Hypertension Management: Links and Risk for Cardiovascular Disease

2021 ◽  
Vol Volume 14 ◽  
pp. 179-187
Author(s):  
Brian Gaffney ◽  
Alan P Jacobsen ◽  
Abhishek W Pallippattu ◽  
Niall Leahy ◽  
John W McEvoy
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Diastolic Blood Pressure ◽  
Hypertension Management ◽  
J Curve

scholarly journals Hypertension and coronary heart disease. Is there a J-curve for diastolic blood pressure?

Cor et Vasa ◽  
2006 ◽  
Vol 48 (10) ◽  
pp. 345-350
Author(s):  
Jiří Widimský
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Diastolic Blood Pressure ◽  
J Curve
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