scholarly journals Association of Transit Time With Cold Ischemic Time in Kidney Transplantation

2021 ◽  
Vol 4 (12) ◽  
pp. e2141108
Author(s):  
Andrew M. Placona ◽  
Casey Humphries ◽  
Chris Curran ◽  
Woodlhey Ambroise ◽  
Jeffrey P. Orlowski ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Transit Time ◽  
Ischemic Time ◽  
Cold Ischemic Time

scholarly journals Kidney transplant outcomes after medical assistance in dying

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Patrick P. Luke ◽  
Anton Skaro ◽  
Alp Sener ◽  
Ephraim Tang ◽  
Max Levine ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Large Scale ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Medical Assistance ◽  
Ischemic Time ◽  
Transplant Outcomes ◽  
Medical Assistance In Dying ◽  
Cold Ischemic Time ◽  
The Mean

Introduction: After nearly four years of Canadian experience with medical assistance in dying (MAiD), the clinical volume of organ transplantation following MAiD remains low. This is the first Canadian report evaluating recipient outcomes from kidney transplantation following MAiD. Methods: This was a retrospective review of the first nine cases of kidney transplants following MAiD at a Canadian transplant center. Results: Nine patients underwent MAiD followed by kidney retrieval during the study period. Their diagnoses were largely neuromuscular diseases. The mean warm ischemic time was 20 minutes (standard deviation [SD] 7). The nine recipients had a mean age of 60 (SD 19.7). The mean cold ischemic time was 525 minutes (SD 126). Delayed graft function occurred in only one patient out of nine. The mean 30-day creatinine was 124 umol/L (SD 52) . The mean three-month creatinine was 115 umol/L (SD 29). Conclusions: We report nine cases of kidney transplantation following MAiD. The process minimized warm ischemia, resulting in low delayed graft function rates, and acceptable post-transplant outcomes. Further large-scale research is necessary to optimize processes and outcomes in this novel clinical pathway.

scholarly journals COST EFFECTIVENESS OF MACHINE PERFUSION USE AFTER LONG COLD ISCHEMIC TIME IN A KIDNEY TRANSPLANTATION PROGRAM

2016 ◽  
Vol 19 (3) ◽  
pp. A302
Author(s):  
D.T. Malheiro ◽  
A.C. Matos ◽  
S. Morgado ◽  
A. Kanamura ◽  
A. Pacheco-Silva
Keyword(s):  
Kidney Transplantation ◽  
Cost Effectiveness ◽  
Machine Perfusion ◽  
Ischemic Time ◽  
Cold Ischemic Time ◽  
Transplantation Program

scholarly journals Assessment of risk factors for hospital readmission after kidney transplantation

2021 ◽  
Author(s):  
Mahmoud Tavakkoli ◽  
Amir Yarahmadi ◽  
Mahin Ghorban Sabbagh ◽  
Mona Najaf Najafi ◽  
Milad Tavakoli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Hospital Readmission ◽  
Intraoperative Complications ◽  
Demographic Data ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Post Discharge ◽  
Ischemic Time ◽  
Cold Ischemic Time

Background and Purpose: Hospital readmission after kidney transplantation is a real challenge for both patients and healthcare systems. Assessment of the risk factors of readmission after kidney transplantation is vital and can reduce morbidity and cost in transplant recipients and donors. The aim of the current study was to determine the risk factors of hospital readmission in patients undergoing kidney transplantation in Montaserieh Hospital of Mashhad, northeast of Iran. Materials and Methods: This retrospective study included 523 first kidney transplant patients between January 2013 and March 2019 from the Montaserieh Hospital Information System (HIS) of Mashhad, Iran. Every-time readmission was the study primary outcome. Donors and recipient's demographic data, recipient's comorbidities, reasons for end-stage renal disease (ESRD), panel reactive antibody (PRA) status, dialysis parameters, cold ischemic time, and delayed graft function (DGF) were the potential risk factors. Statistical analysis was done using Chi-square and Student's t-test. Results: Data from 523 patients were assessed for potential eligibility. Based on the exclusion criteria, data from 479 patients were included in the final analysis. 174 (36.3%) patients were never readmitted, and 305 (63.7%) were readmitted at least once post-discharge. 39 (12.8%) were readmitted within the first-month post-discharge. Older age, sex, higher prevalence of comorbidities, diabetes and hypertension, duration of primary disease before transplantation, hemodialysis and duration of pre-transplant dialysis, mean pre-transplant platelet count, intraoperative complications, increased cold ischemic time, and delayed graft function were associated with a higher prevalence of readmission (p<0.05). Conclusion Our results showed that different independent variables and patients' comorbidities were important risk factors for readmission after kidney transplantation. Early prediction of these risk factors could result in prevention from readmission in patients undergoing kidney transplantation.

The Impact of Virtual Crossmatch on Cold Ischemic Times and Outcomes Following Kidney Transplantation

2020 ◽  
pp. 000313482094218
Author(s):  
Sadaf Aslam ◽  
Jacentha Buggs ◽  
Kasey Wyatt ◽  
Ambuj Kumar ◽  
Ebonie Rogers ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Small Sample Size ◽  
Graft Function ◽  
Human Leukocyte ◽  
Small Sample ◽  
Donor Pool ◽  
Ischemic Time ◽  
Post Transplant ◽  
Cold Ischemic Time ◽  
The Impact

Background Prolonged cold ischemic time (CIT) in deceased donor kidney transplantation (DDKT) has been associated with adverse graft outcomes. Virtual crossmatch (VXM) facilitates reliable prediction of crossmatch results based on the profile of human leukocyte antigen antibodies of the recipient and the donor in reduced time compared with a physical crossmatch (PXM). We hypothesized a shorter CIT since the implementation of the VXM in recipients of DDKT. Methods We conducted a retrospective cohort study of consecutive adult recipients of DDKT. The data were analyzed for differences in CIT before and after the implementation of VXM. Results After the exclusion of 59 recipients (age less than 18 years and/or CIT ≥ 20 hours), our study compared outcomes of 81 PXMs from February to June 2018 against 68 VXMs from February to June 2019. There were no statistical differences between groups based on donor age ( P = .09), donor type ( P = .38), kidney donor profile index ( P = .43), or delayed graft function ( P = .20). Recipients with VXM were older (58 vs 51 years , P = .002) and had a higher estimated post-transplant survival score (59% vs 46% , P = .01). The CIT was significantly lower for the VXM group ( P = .04). Conclusion Our study demonstrated a significantly shorter CIT with VXM in DDKT recipients. Our study was limited with small sample size, but the trend of increased graft survival with higher estimated post-transplant scores and older recipients is encouraging as the donor pool expands with marginal kidneys and national sharing.

DETERMINATION OF A “SAFE” COLD ISCHEMIC TIME IN KIDNEY TRANSPLANTATION - A COMPARISON OF FIRST AND SECOND KIDNEY TRANSPLANTS FROM THE SAME DECEASED DONOR

2009 ◽  
Vol 181 (4S) ◽  
pp. 809-809
Author(s):  
Markus Giessing ◽  
Florian Fuller ◽  
Frank Friedersdorff ◽  
Lutz Liefeldt ◽  
Kurt Miller ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Deceased Donor ◽  
Kidney Transplants ◽  
Ischemic Time ◽  
Cold Ischemic Time

scholarly journals Hubungan antara Total Waktu Iskemik pada Transplan Ginjal dengan Lama Perawatan di Rumah Sakit: A Single Center Report

2020 ◽  
Vol 7 (1) ◽  
pp. 41-45
Author(s):  
Eriawan Agung Nugroho ◽  
Muhamad Azwin Kamar ◽  
Ardy Santosa ◽  
Nanda Daniswara ◽  
Sofyan Rais Addin
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Delay Graft Function ◽  
Therapeutic Modality ◽  
Ischemic Time ◽  
Warm Ischemic Time ◽  
Cold Ischemic Time ◽  
Hospitalization Time ◽  
End Stage ◽  
Spearman Test

Latar Belakang : Transplantasi ginjal diakui sebagai kemajuan utama pengobatan modern yang memberikan kehidupan berkualitas tinggi kepada pasien penyakit ginjal stadium akhir (End Stage Renal Disease). Waktu iskemik dingin /Cold Ischemic Time (CIT) telah ditemukan sebagai faktor risiko independen yang penting untuk delay graft function (DGF) pada transplantasi ginjal. Terdapat informasi terbaru bahwa waktu iskemik hangat /Warm Ischemic Time (WIT) yang lama dapat mengurangi kelangsungan hidup graft dalam donor hidup transplantasi ginjal. Tujuan dari penelitian ini adalah untuk mengevaluasi hubungan total ischemik time selama operasi penerima dengan lama rawat inap. Metode : Penelitian ini merupkaan studi observational-cross sectional. Data didapatkan dari catatan medis pasien yang telah menjalani transplantasi ginjal dari Januari 2014 – Desember 2018 du RS Umum dr. Kariadi semarang. Terdapat 28 pasien, 18 diantaranya adalah laki-laki dan 10 adalah wanita. Data total waktu iskemik dibandingkan dengan lamanya rawat inap. Data dianalisa dengan tes Spearman menggunakan software SPSS versi 23. Hasil : Pada studi ini menunjukkan adanya korelasi yang signifikan antara total waktu iskemik dengan lama perawatan di rumah sakit (p<0.001). Akan tetapi, umur donor tidak mempengaruhi total waktu iskemik (p=0.673), tidak signifikan (signifikan jika p<0.005). Simpulan : Adanya hubungan yang signifikan antara total waktu iskemik dengan lama perawatan rumah sakit. Namun, tidak ditemukannya hubungan yang signifikan pada usia donor dan total waktu iskemik. Kata kunci: total waktu iskemik, lama perawatan, transplantasi ginjal   Background: Kidney transplantation is recognized as an advanced modern therapeutic modality, providing a better life for patients with end stage renal failure globally. Cold Ischemic Time (CIT) has been found as an important independent risk factor for delay graft function (DGF) in kidney transplantation. DGF also associated with patient’s survival post-operatively. Recent studies suggested that prolonged Warm Ischemic Time (WIT) may decrease graft’s survival in living kidney transplantation donor. This study aimed to evaluate the total ischemic time during recipient surgery and accessed its contribution for hospitalization time in kidney transplantation patients. Methods: This is a descriptive retrospective study. This study was started in 2014 until December 2018, including data from patients’ medical record whom underwent kidney transplantation in Kariadi General Hospital Semarang. Data was collected from 28 patients, including 18 male patients and 10 female patients. The author found a significant correlation between patient’s age and total ischemic time. Total ischemic time also compared with hospitalization time. Data was processed using Spearman test in SPSS software. Results: Based on Spearman test, Total ischemic time was significantly correlated with hospitalization time (p < 0.001). However, donor’s age did not affect prolonged total ischemic time with p = 0.673, which is not significant (significant if p value < 0.05). Conclusion: Total ischemic time has a significant correlation with hospitalization time. In contrary, no significant correlation between donor’s age and prolonged total ischemic time. Key Words: Total ischemic time, hospitalization time, kidney transplantation

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