Today's Science, Tomorrow's Patient: the Pivotal Role of Tissue, Clinical Data and Informatics in Modern Drug Development

Cancer Bioinformatics ◽

10.1002/0470032898.ch11 ◽

2006 ◽

pp. 185-209

Author(s):

Kirstine Knox ◽

Amanda Taylor ◽

David J. Kerr

Keyword(s):

Drug Development ◽

Clinical Data ◽

Pivotal Role ◽

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Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2092 ◽

2020 ◽

Vol 109 (1) ◽

pp. 51-54

Author(s):

Karen Rowland Yeo ◽

Karthik Venkatakrishnan

Keyword(s):

Drug Development ◽

Mass Balance ◽

Pivotal Role ◽

Pharmacokinetic Models ◽

Balance Study ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Mass Balance Study

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The role of molecular imaging in modern drug development

Drug Discovery Today ◽

10.1016/j.drudis.2014.01.003 ◽

2014 ◽

Vol 19 (7) ◽

pp. 936-948 ◽

Author(s):

Lídia Cunha ◽

Krisztián Szigeti ◽

Domokos Mathé ◽

Luís F. Metello

Keyword(s):

Molecular Imaging ◽

Drug Development ◽

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The Role of Phase III Trials in Modern Drug Development

Cancer Drug Discovery and Development - Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ◽

10.1007/978-1-4614-9135-4_38 ◽

2013 ◽

pp. 763-783

Author(s):

Janet E. Murphy ◽

Lecia V. Sequist ◽

Bruce A. Chabner

Keyword(s):

Drug Development ◽

Phase Iii ◽

Modern Drug ◽

Phase Iii Trials

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458 Pivotal role of NADPH oxidase in cardiac contractile dysfunction and fibrosis induced by chronic pressure-overload

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90283-9 ◽

2003 ◽

Vol 2 (1) ◽

pp. 93

Author(s):

D GRIEVE ◽

J BYRNE ◽

A CAVE ◽

A SHAH

Keyword(s):

Nadph Oxidase ◽

Pressure Overload ◽

Pivotal Role ◽

Contractile Dysfunction ◽

Cardiac Contractile ◽

Cardiac Contractile Dysfunction

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943-P: Role of Model-Informed Drug Development in Confirming Additional Clinical Benefits of Dulaglutide

Diabetes ◽

10.2337/db20-943-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 943-P

Author(s):

LAI-SAN THAM ◽

JEANNE GEISER ◽

CHENG CAI TANG ◽

KAREN SCHNECK ◽

DAVID COX ◽

...

Keyword(s):

Drug Development ◽

Clinical Benefits

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Faculty Opinions recommendation of Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021055.241470 ◽

2004 ◽

Author(s):

Pekka Lappalainen

Keyword(s):

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Faculty Opinions recommendation of Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5896957.5887055 ◽

2010 ◽

Author(s):

Lorenz Hirt

Keyword(s):

Brain Injury ◽

Pivotal Role ◽

Interleukin 17 ◽

Ischemic Brain Injury ◽

Ischemic Brain ◽

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Faculty Opinions recommendation of Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717970990.793469383 ◽

2013 ◽

Author(s):

Achsah Keegan

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Transcriptional Activation ◽

Lung Fibrosis ◽

Type I Collagen ◽

Tissue Growth ◽

Pivotal Role ◽

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Faculty Opinions recommendation of Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718003609.793475629 ◽

2013 ◽

Author(s):

Richard L Stevens

Keyword(s):

Mast Cell ◽

Pivotal Role ◽

Endothelin 1 ◽

Mast Cell Protease ◽

Mouse Mast Cell

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Faculty Opinions recommendation of Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735522022.793559502 ◽

2019 ◽

Author(s):

Indu Ambudkar ◽

Hwei Ling Ong

Keyword(s):

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