Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models

FEBS Letters ◽  
2021 ◽  
Author(s):  
Cristian Rocha‐Roa ◽  
Juan David Orjuela ◽  
Chad Leidy ◽  
Pilar Cossio ◽  
Camilo Aponte‐Santamaría
Keyword(s):  
Pore Formation ◽  
Bacterial Membrane ◽  
Membrane Models

The Influence of Rifabutin on Human and Bacterial Membrane Models: Implications for Its Mechanism of Action

2013 ◽  
Vol 117 (20) ◽  
pp. 6187-6193 ◽  
Author(s):  
Marina Pinheiro ◽  
Cláudia Nunes ◽  
João M. Caio ◽  
Cristina Moiteiro ◽  
Marlene Lúcio ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Bacterial Membrane ◽  
Membrane Models

Molecular Dynamics Studies on the Bacterial Membrane Pore Formation by Small Molecule Antimicrobial Agents

2021 ◽  
Author(s):  
Felsis Angelene Daison ◽  
Nitheeshkumar Kumar ◽  
Siranjeevi Balakrishnan ◽  
Kavyashree Venugopal ◽  
Sangamithra Elango ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Small Molecule ◽  
Pore Formation ◽  
Antimicrobial Agents ◽  
Bacterial Membrane ◽  
Membrane Pore

scholarly journals Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

2021 ◽  
Vol 22 (22) ◽  
pp. 12401
Author(s):  
Tadsanee Awang ◽  
Phoom Chairatana ◽  
Ranjit Vijayan ◽  
Prapasiri Pongprayoon
Keyword(s):  
Molecular Dynamics ◽  
Host Defense ◽  
Pore Formation ◽  
Md Simulations ◽  
Bacterial Membrane ◽  
Binding Mechanism ◽  
Gram Negative ◽  
Host Defense Peptide ◽  
Human Defensin 5 ◽  
Binding Mechanisms

Human α-defensin 5 (HD5) is a host-defense peptide exhibiting broad-spectrum antimicrobial activity. The lipopolysaccharide (LPS) layer on the Gram-negative bacterial membrane acts as a barrier to HD5 insertion. Therefore, the pore formation and binding mechanism remain unclear. Here, the binding mechanisms at five positions along the bacterial membrane axis were investigated using Molecular Dynamics. (MD) simulations. We found that HD5 initially placed at positions 1 to 3 moved up to the surface, while HD5 positioned at 4 and 5 remained within the membrane interacting with the middle and inner leaflet of the membrane, respectively. The arginines were key components for tighter binding with 3-deoxy-d-manno-octulosonic acid (KDO), phosphates of the outer and inner leaflets. KDO appeared to retard the HD5 penetration.

Bacterial membrane binding and pore formation abilities of carbohydrate recognition domain of fish lectin

2017 ◽  
Vol 67 ◽  
pp. 202-212 ◽  
Author(s):  
Abirami Arasu ◽  
Venkatesh Kumaresan ◽  
Rajesh Palanisamy ◽  
Mariadhas Valan Arasu ◽  
Naif Abdullah Al-Dhabi ◽  
...  
Keyword(s):  
Pore Formation ◽  
Membrane Binding ◽  
Bacterial Membrane ◽  
Carbohydrate Recognition Domain ◽  
Carbohydrate Recognition
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