Neurotransmitter Function in Impulsive Aggression and Intermittent Explosive Disorder

Author(s):  
Jennifer R. Fanning ◽  
Royce Lee ◽  
Emil F. Coccaro
2015 ◽  
Vol 61 ◽  
pp. 135-140 ◽  
Author(s):  
Emil F. Coccaro ◽  
Oscar Solis ◽  
Jennifer Fanning ◽  
Royce Lee

CNS Spectrums ◽  
1999 ◽  
Vol 4 (S3) ◽  
pp. 16-21
Author(s):  
Eric Hollander ◽  
Jennifer Rosen ◽  

AbstractTwo symptom clusters within the obsessive-compulsive (OC) spectrum—the impulsive cluster and the schizo-obsessive cluster—are discussed in this paper. Disorders characterized by impulsivity include disorders of impulse control (eg, intermittent explosive disorder, pyromania, kleptomania, pathologic gambling, trichotillomania); paraphilias, sexual impulsions, and sexual addictions; and impulsive aggression personality disorders (eg, borderline, antisocial, histrionic, and narcissistic personality disorders). The schizo-obsessive cluster includes comorbid symptoms of obsessive-compulsive disorder (OCD) and schizophrenia. Both clusters of disorders have a substantial impact on individuals and society. This article examines the overlap of symptoms between OCD and OC spectrum disorders, along with possible treatment options. Studies on the effectiveness of serotonin reuptake inhibitors in treating pathologic gambling, compulsive buying, and comorbid OCD and schizophrenia are presented. The need for additional large scale, adequately-controlled studies is discussed.


2000 ◽  
Vol 14 (2_suppl1) ◽  
pp. S39-S44 ◽  
Author(s):  
E. Hollander ◽  
J. Rosen

Disorders characterized by impulsivity include disorders of impulse control (intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania), paraphilias, sexual impulsions and sexual addictions and impulsive aggression personality disorders (borderline, antisocial, histrionic and narcissistic personality disorders). Impulsivity has a substantial impact on both individuals and society. Impulse control disorders may be conceptualized as a subset of the obsessive-compulsive spectrum. In this article, we examine the genetic and neurobiological aetiology of these disorders and possible treatment options. The link between serotonergic dysfunction and the pathophysiology of impulsivity is discussed, and studies that examine the efficacy of various selective serotonin reuptake inhibitors and other alternatives in the treatment of impulsive disorders such as pathological gambling, sexual addictions and borderline personality disorder are presented.


2008 ◽  
Author(s):  
William Fisher ◽  
Dan T. Matthews ◽  
Larry Fisher ◽  
Natalie Ceballos
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