Total failure of fertilization after conventional IVF – rescue ICSI

Abstract Background Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasmic sperm injection (ICSI) has become the first choice over conventional in vitro fertilization (IVF) procedures although evidence of improved results is still debated and its use in couples without male factor infertility is not recommended. Among the strategies potentially useful to promote the use of conventional IVF, we herein call attention to the late rescue ICSI, which consists in performing ICSI after 18–24 h from conventional insemination on oocytes that show no signs of fertilization. This treatment has however been reported to be associated with a low success rate until recent observations that embryos derived from late rescue ICSI may be transferred after cryopreservation in a frozen-thawed cycle with improved results. The aim of the present study was to assess whether frozen embryos deriving from rescue ICSI performed about 24 h after conventional IVF may represent a valuable option for couples experiencing fertilization failure. Methods A systematic review on the efficacy of late rescue ICSI was performed consulting PUBMED and EMBASE. Results Including twenty-two original studies, we showed that clinical pregnancy rate per embryo transfer and implantation rate obtainable with fresh embryo transfers after rescue ICSI are not satisfactory being equal to 10 and 5%, respectively. The transfer of cryopreserved rescue ICSI embryos seems to offer a substantial improvement of success rates, with pregnancy rate per embryo transfer and implantation rate equal to 36 and 18%, respectively. Coupling rescue ICSI with frozen embryo transfer may ameliorate the clinical pregnancy rate for embryo transfer with an Odds Ratio = 4.7 (95% CI:2.6–8.6). Conclusion Results of the present review support the idea that r-ICSI coupled with frozen embryo transfer may overcome most of the technical and biological issues associated with fresh transfer after late r-ICSI, thus possibly representing an efficient procedure for couples experiencing fertilization failure following conventional IVF cycles. Trial registration Prospero registration ID: CRD42021239026.

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Discovery of total failure of the traditional laws of reflection and refraction of light to explain the phenomena of reflection and refraction

Optik ◽

10.1016/j.ijleo.2021.166923 ◽

2021 ◽

Vol 240 ◽

pp. 166923

Author(s):

Pramode Ranjan Bhattacharjee

Keyword(s):

Reflection And Refraction ◽

Total Failure

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Partial triumph or total failure?

The Mathematical Intelligencer ◽

10.1007/bf03024176 ◽

1985 ◽

Vol 7 (2) ◽

pp. 55-58 ◽

Cited By ~ 2

Author(s):

Raymond G. Ayoub

Keyword(s):

Total Failure

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Application of Immediate Dentoalveolar Restoration in Alveolus Compromised with Loss of Immediate Implant in Esthetic Area

Case Reports in Dentistry ◽

10.1155/2018/1672170 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11

Author(s):

Rafael de Lima Franceschi ◽

Luciano Drechsel ◽

Guenther Schuldt Filho

Keyword(s):

Gingival Tissue ◽

Mechanical Trauma ◽

Sports Activity ◽

Photographic Analysis ◽

Total Failure ◽

Immediate Implants ◽

Subepithelial Connective Tissue Graft ◽

Immediate Implant ◽

The Stability ◽

Maxillary Tuberosity

In the reported clinical case, the immediate dentoalveolar restoration (IDR) technique was applied to reconstruct the buccal bone wall, with autogenous graft of the maxillary tuberosity, which had been lost due to a root fracture, and to provide the necessary bone substrate for the installation of an implant and its provisioning. One of the greatest risks inherent in the survival of immediate implants is the maintenance of their stability during the healing period. In this case, due to a mechanical trauma in sports activity in the first postoperative month, there was a total failure in the osseointegration process, confirmed by tomographic examination of both the implant and the bone graft. The deleterious effects of this accident were compensated with a new approach and reapplication of IDR technique using a smaller-diameter implant and with conical macrogeometry in conjunction with the new bone reconstruction under the same compromised alveolus; associated, after the period of osseointegration, with the maneuvers of volume increase of the gingival tissue by subepithelial connective tissue graft. The tomographic result demonstrated the success of the surgical procedures, and the clinical/photographic analysis obtained showed the stability of the gingival margin without compromising the esthetic result of the prosthetic restoration.

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